Carthera

Assistance Publique-hopitaux De Paris

Sorbonne Université

Université Pierre Et Marie Curie (Paris 6)

Other

Cerebral Therapeutics, Inc.

Michael Canney

Alexandre Carpentier

Francois Lacoste

Guillaume Bouchoux

Jean-Yves Chapelon

Cyril Lafon

Alexandre Vignot

An Nguyen-Dinh

Françoise Chavrier

Rémi Dufait

Daniel J Abrams

Matthieu Cholvy

William Apoutou N'Djin

Christophe Notard

François Lacoste

Kévin Beccaria

An assembly for imaging and/or treating brain tissue, having at least one acoustic window which comprises a plate that is transparent to ultrasonic waves, and at least one positioning marker which facilitates positioning of a probe for generating ultrasonic waves so as to be aligned with said acoustic window.

Assembly for imaging and/or treating brain tissue

The present invention relates to a method for controlling a probe for the treatment of brain tissue using an assembly comprising the probe and an acoustic window (), the probe () including a plurality of transducers () for generating ultrasound waves, the method comprising: —a phase of detection: •of the probe transducers situated above the cranium () of the patient, and •of the probe transducers situated above the acoustic window (), so as to permit: •deactivation of the transducers situated above the cranium () of the patient, •activation of the transducers situated above the acoustic window ().

Control method for the treatment of brain tissue using an ultrasonic probe and an implanted acoustic window on the cranium

An apparatus having an implantable ultrasound generating treating device to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, includes several ultrasound generating transducers, which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers each have one or several operating frequencies. The transducers include the group of transducers having several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers. The apparatus is also used to treat brain disorders.

Implantable ultrasound generating treating device for brain treatment, apparatus comprising such device and method implementing such device

The present invention relates to a pathology treatment apparatus comprising:

Method and system for detecting a fault in an electrical connection between an ultrasound device and a remote control unit

In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container. In some embodiments, the catheter may include an aspiration lumen and an infusion lumen. A distal end of the intraventricular portion of the catheter may be positionable, during use, in a subject's brain fluid. In some embodiments, the container may be coupled to a proximal end of the aspiration lumen. The proximal end of the aspiration lumen may be in fluid communication with the container. In some embodiments, the container may include a barrier positioned between a proximal opening of the aspiration lumen and at least a portion of the infusion lumen adjacent to and/or associated with the container. The barrier may inhibit penetration of a surgical instrument.

Implantable intraventricular sampling and infusion access device

The present invention relates to an ultrasonic probe for heating, internally, an ultrasonically absorbent target medium, the probe comprising: at least one piezoelectric transducer () having a front face () intended to be positioned facing the target medium and a back face () opposite the front face (), the transducer being able to emit at least one primary wave emanating from its front face and at least one secondary wave emanating from its back face, the probe being noteworthy in that it furthermore comprises: a reflector () facing the back face () of the transducer (), the reflector () being suitable for reflecting the secondary wave emitted by the transducer (); and a cooling-fluid layer () between the transducer () and the reflector ().

Ultrasonic thermal ablation probe

An interstitial ultrasound thermal ablation applicator for conformal treatment of an inhomogeneous tumor lesion includes: a body having a longitudinal axis; and a plurality of array transducers mounted on the body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer faces disposed in a polygonal arrangement; the plurality of array transducers having predetermined elevation dimensions defined for directing emitted ultrasonic energy to obtain a conformal volume treatment of the tumor lesions. An electronic driving method for driving an applicator having multiple independent transducer elements arranged in rows and columns includes: controlling focal parameters of each row and column of transducer elements; and controlling a contribution of each row and column of transducer elements in a manner to provide a conformal ablated volume.

Interstitial ultrasonic disposable applicator and method for tissue thermal conformal volume ablation and monitoring the same

The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.

Method for transiently disrupting a region of the blood-brain barrier of a human

The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator () made of non-ferromagnetic material comprising a casing (), an ultrasound generating treating device () positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means () to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.

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Denver, CO, United States of America

Michael Canney