Bristol-myers Squibb Compnay

Bristol-myers Company

Michael C Tao

John R Euber

Ronald C Fuller

J Roberto Moran

Salim S Akrabawi

Richard E Litov

An improved oral rehydration solution comprising a mixture of rice dextrin and required electrolytes is provided. The functionality of the rice dextrin in oral rehydration solutions is superior to glucose in infants with chronic diarrhea resulting in lower stool output and enhanced water retention. Rice dextrin also has a polymer profile which provides more readily available glucose than corn dextrin or rice fluor. There is also provided a process for clarifying solutions of rice dextrin which involves a first filtration at 35.degree. C. and 50.degree. C. and a second filtration at temperatures above 80.degree. C. using filter aid and activated carbon.

Rice dextrin oral rehydration solution

A unit dose package, which is usable with a bottle to reconstruct the contents of the package, has a plastic fitment which defines a mouth opening for the package. The plastic fitment is bonded to a wall of the package and has a channel which receives the neck of the bottle. A flexible foil membrane seal is removably attached to this plastic fitment and is covered by a protective overcap.

Unit dose package

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Evansville, IN, United States of America

Michael C Tao