Affymetrix, Inc.

Affymax Technologies, N.v.

Duke University

University of California

Leland Stanford Junior University

Michigan State University

J. Leighton Read

Michael C. Pirrung

Lubert Stryer

Stephen P. A. Fodor

Affymax N.v.

Michael C Pirrung

J Leighton Read

Stephen P A Fodor

Stephen P Fodor

Ronald W Barrett

Steven A Sundberg

Christopher P Holmes

Paul D Hoeprich, Jr

Stephen Pa Fodor

Andre Bachmann

Steven W Shuey

Jean-Claude Bradley

Johannes Rudolph

Nicole A Bakas

Gerald M McGeehan

Luburt Stryer

Xiadong Zhao

Yong Rok Lee

The disclosure provides for compounds having immunoproteasome inhibitory activity, and pharmaceutical compositions made thereof. The disclosure further provides for the use of the compounds and compositions in treating various diseases and disorders in a subject that are associated with immunoproteasome activity, including inflammatory disorders, autoimmune disorders, hematological disorders, and neurodegenerative disorders.

Immunoproteasome inhibitor analogs

The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.

Synthesis of syrbactin proteasome inhibitors

The disclosure provides for novel compounds which have proteasome inhibitory activity, pharmaceutical compositions made thereof, and methods of use thereof to treat various disorders, including cancer and nonmalignant tumors.

Substituted macrocyclic compounds having proteasome inhibitory activity

Compounds of Formula I are described along with pharmaceutical formulations thereof, and methods of treating disorders such as diabetes and neurodegenerative diseases with such compounds.

Small molecule insulin mimetics absent quinones

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Nucleotides and analogs having photoremovable protecting groups

Pyrrolylquinones and indolylquinones useful for treating diseases such as neurodegenerative disease, viral infections and proliferative disease are described, along with methods of making such compounds and pharmaceutical formulations containing such compounds.

Heterocyclic quinones as pharmaceutical agents

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Apparatus comprising polymers

The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.

Polypeptide arrays

A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.

Methods for polymer synthesis

Apparatus for polymer synthesis

Nucleic acid reading and analysis system

Methods of synthesizing a plurality of different polymers on a surface of a substrate

Growing community of inventors

Chapel Hill, NC, United States of America

Michael C Pirrung