University of Minnesota

Princeton University

US Government As Represented by the Secretary of the Army

Michael C McAlpine

Yong Lin Kong

Ghazaleh Haghiashtiani

Blake N Johnson

Zhijie Zhu

Steven John Koester

John Bischof

Angela Panoskaltsis-Mortari

Suhasa B Kodandaramaiah

Robert M Sweet

Ruitao Su

Manu Sebastian Mannoor

Kanav Khosla

Yi Qi

Guebum Han

Leila Ghanbari

Daniel Sousa Schulman

Sarah Swisher

Kieran T Smith

Preston Donaldson

Fanben Meng

Kaiyan Qiu

Shuangzhuang Guo

Manu Sebastian-Mannoor

Joshua Uzarski

A system includes a placement head with at least one printing nozzle configured to pick up and detachably hold at least one biological organism; an image acquisition system including a visual inspection system configured to identify at least one target biological organism to be picked up by the printing nozzle of the placement head in a first location, and identify at least one second location for deposit of the at least one target biological organism, wherein the first location is different from the at least one second location; and a robotic motion system that moves the placement head, based on input from the visual inspection system and a distance identification system, from the first location to the at least one second location, such that the placement head deposits the target biological organism at the at least one second location.

Three dimensional placement of organisms

A system and method is provided for imaging and monitoring a tissue, such as a cerebral cortex, of a subject. Access to imaging a tissue, such as cerebral cortex, may be provided by removing a portion of a bone, such as a portion of a skull of the subject. A prosthesis, such as an optically transparent prosthesis, may be used to replace the portion of the skull removed and may be conformed to the same 3D contour of the bone that was removed. A data acquisition system, such as an imaging system, may then be affixed to the skull prosthesis and may be used to acquire image data of the tissue of the subject at high spatial and temporal resolution and without interference from intervening bone material.

Systems and methods for multimodal neural sensing

The disclosure describes a head gimbal assembly including a suspension and a damping layer on a surface of the suspension. The suspension may include a slider mount configured to establish mechanical communication with a slider and the layer may be displaced from the slider mount. The layer may be configured to provide passive damping or active damping.

Head gimbal assembly with damping material

A printed structure including a plurality of overlying layers of elongate polymeric filaments stacked on a surface of a substrate. The elongate polymeric filaments are stacked on each other along their lengths to form a liquid impermeable, self-supporting wall. The liquid impermeable self-supporting wall forms a wall angle of about 30&#xb0; to about 90&#xb0; with respect to a plane of the surface of the substrate.

Additively manufactured self-supporting microfluidics

Systems and techniques are described for additive manufacturing, e.g., 3D printing, a component on an unconstrained freeform build surface. The systems and techniques may allow determining a 3D trajectory and/or deformation of a target deposition region on the build surface by determining a relative location of at least one registration feature on the build surface. Control circuitry may control, based on the 3D trajectory and/or deformation and based on a build model of the component, at least one dispenser to cause dispensing of at least one composition from the at least one dispenser in a predetermined pattern on or adjacent to the target deposition region. The predetermined pattern of the composition defines at least one portion of the component.

Additive manufacturing on unconstrained freeform surfaces

A 3D-printed in vitro model biological microenvironment in examples discussed below may have one or more of the following features: (a) a gel matrix 3D-printed scaffold, wherein the gel matrix comprises a chemical composition configured to culture a first type of live cells, (b) a target chemical disposed at one or more locations within the gel matrix, the target chemical forming a chemical depot from which a chemical gradient is created within the gel matrix, (c) a conduit disposed within the gel matrix and defining a lumen comprising a second type of live cells, wherein the conduit is configured to enable at least some of the first type of live cells to migrate through the conduit and facilitate flow of at least: some of the live cells to an outlet of the conduit, or enable introduction of at least one of other cells, Achemical mediators, or drugs into the 3D-printed microenvironment.

3D-printed models of biological microenvironments

An organ model comprises a polymer body formed from one or more selectively deposited substructures of a printable polymer-based ink composition, wherein the one or more selectively deposited substructures form a printed geometrical structure that corresponds to at least a portion of an anatomical structure of an organ, wherein a formulation of the printable polymer-based ink is selected such that the printed geometrical body has one or more material properties that match or substantially match one or more corresponding tissue material properties of an organ tissue, and an electronic device integrated onto a surface or into a structure of the printed geometrical structure.

3D printed organ model with integrated electronic device

Techniques are described for additive manufacturing, e.g., 3D printing, stretchable tactile sensors. As described, the techniques may allow the stretchable tactile sensors to be 3D printed under ambient conditions via nanocomposite inks. In various embodiments, sinter-free inks are described with adjustable viscosities and electrical conductivities. Moreover, conductive compositions are described in which micron or submicron-sized silver particles are dispersed in a highly stretchable silicone elastomer. Techniques are described herein in which the inks are used 3D printing process to form tactile sensing platforms and integrated arrays.

Additively manufactured flexible electronic sensors and conductive compositions used therein

Disclosed is a process whereby diverse classes of materials can be 3D printed and fully integrated into device components with active properties. An exemplary embodiment shows the seamless interweaving of five different materials, including (1) emissive semiconducting inorganic nanoparticles, (2) an elastomeric matrix, (3) organic polymers as charge transport layers, (4) solid and liquid metal leads, and (5) a UV-adhesive transparent substrate layer, demonstrating the integrated functionality of these materials. Further disclosed is a device for printing these fully integrated 3D devices.

3D printed active electronic materials and devices

The present invention includes biomimetic nerve conduits that can be used as nerve regeneration pathways. The present invention further provides methods of preparing and using biomimetic nerve conduits. The disclosed compositions and methods have a broad range of potential applications, for example replacing a missing or damaged section of a nerve pathway of a mammal.

Method of producing a 3D subject specific biomimetic nerve conduit

A bioelectronic device and method of making is disclosed. The device includes a scaffold formed via 3D printing. The device also includes a biologic and an electronic device formed via 3D printing, the biologic and electronic device being interweaved with or coupled to the scaffold. The electronic component may e.g., include at least one of hard conductors, soft conductors, insulators and semiconductors. The scaffold may be formed of at least one of synthetic polymers and natural biological polymers. The biologic may include at least one of animal cells, plant cells, cellular organelles, proteins and DNA (including RNA).

Multi-functional hybrid devices/structures using 3D printing

A method of making a flexible piezoelectric structure is disclosed. A piezoelectric film is deposited by film deposition on a planar substrate. A biocompatible flexible substrate is contacted with the piezoelectric film. The piezoelectric film and biocompatible flexible substrate are separated from the planar substrate, and the piezoelectric film remaining is attached to the biocompatible flexible substrate.

Method of manufacturing flexible piezoelectric structures

A biosensor and method of making are disclosed. The biosensor is configured to detect a target and may include a peptide immobilized on a sensing component, the sensing component having an anode and a cathode. The immobilized peptide may comprise an antimicrobial peptide binding motif for the target. The sensing component has an electrical conductivity that changes in response to binding of the immobilized peptide to the target. The immobilized peptide may bind one or more targets selected from the list consisting of: bacteria, Gram-negative bacteria, Gram-positive bacteria, pathogens, protozoa, fungi, viruses, and cancerous cells. The biosensor may have a display with a readout that is responsive to changes in electrical conductivity of the sensing component. The display unit may be wirelessly coupled to the sensing component. A resonant circuit with an inductive coil may be electrically coupled to the sensing component. A planar coil antenna may be disposed in proximity to the resonant circuit, the planar coil antenna being configured to provide power to the sensing component.

Growing community of inventors

Minneapolis, MN, United States of America

Michael C McAlpine