Leco Corporation

Michael C Mason

Peter Markel Willis

Viatcheslav Artaev

Julie R Pitz

Mark Russell Wheeler

Mark A Wheeler

A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for processing the ion detection signals and for supplying processed signals to the spectra processing module. The spectra processing module generates spectra from the processed signals and supplies the generated spectra to an external processor for post-processing. The spectra processing module may include an ion statistics filter and/or a peak histogram filtering circuit.

Data acquisition system for a spectrometer using an ion statistics filter and/or a peak histogram filtering circuit

A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for processing the ion detection signals and for supplying processed signals to the spectra processing module. The spectra processing module generates spectra from the processed signals and supplies the generated spectra to an external processor for post-processing. The spectra processing module may include one or more of: a cross-spectra filter for filtering data in each spectra as a function of data in at least one prior spectra; a shaping filter for removing skew and shoulders from the processed signals; a sharpening filter for sharpening the peaks of the processed signals to effectively deconvolve and separate overlapping peaks; an ion statistics filter; and a peak histogram filtering circuit.

Data acquisition system for a spectrometer using various filters

A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector and a processing circuit. The processing circuit may include an initial processing module and a spectra processing module. According to one embodiment, the spectra processing module generates stick spectra and supplies the stick spectra to an external processor. The stick spectra comprise a peak intensity, resolution, and a location in the spectra for each detected peak. The stick spectra may be generated in real time.

Data acquisition system for a spectrometer that generates stick spectra

A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial/transient processing module, and a spectra processing module. The initial/transient processing module is provided for processing the ion detection signals and for supplying processed signals to the spectra processing module. The transient processing module may contiguously sample the ion detection signals at a rate of at least 1.5 GHz. The spectra processing module may generate spectra from the transients at a rate of at least 50 spectra per second. The initial processing module may be configured to have a sensitivity that is sufficient to detect a single ion received within one of over at least 100 transients and to detect and quantify a number of ions simultaneously striking said ion detector up to at least 10 simultaneously striking ions.

Data acquisition system for a spectrometer

A circuit synchronizes the actuation of multi-dimensional separating valves with a system clock also coupled to a data acquisition circuit such that signals from a detector are synchronized and no signal information is lost. The system comprises an acquisition clock coupled to a data acquisition logic system and to a modulator valve control. The modulator valve control is, in turn, coupled to a multi-dimensional separation technique valve unit for controlling the valves for introduction of the eluant from a first separation column to a second, faster column in synchronism with acquisition of data by a detector.

Synchronous data acquisition for multi-dimensional orthogonal liquid separation system

A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector, an initial processing module, and a spectra processing module. The initial processing module is provided for receiving, sampling, and processing ion detection signals received from the ion detector, and for supplying processed signals to the spectra processing module. The initial processing module includes a horizontal accumulation circuit that combines a fractional number of adjacent samples of the ion detection signals into bins. The number of adjacent samples to combine into bins may vary as a function of: (1) the time of arrival at the ion detector corresponding to that sample; (2) the mass corresponding to that sample; (3) the resolution corresponding to that sample; and/or (4) an operational mode of the spectrometer. The spectra processing module receives the processed signals and generates spectra.

Data acquisition system for a spectrometer using horizontal accumulation

A data acquisition system and method are described that may be used with various spectrometers. The data acquisition system may include an ion detector and a processing circuit. The processing circuit may include an initial processing module and a spectra processing module. According to one embodiment, the spectra processing module generates stick spectra and supplies the stick spectra to an external processor. The stick spectra comprise a peak intensity, resolution, and a location in the spectra for each detected peak. The initial processing module may contiguously sample the ion detection signals at a rate matched to the capabilities of the ion detector (up to at least 1.5 GHz) over a full spectral range. The spectra processing module may receive the processed signals and generate spectra from the processed signals at a rate matched to the time response of the separation techniques (up to 200 spectra/second).

Data acquisition system for a spectrometer using an adaptive threshold

A system intended for use in time-of-flight mass spectroscopy for detecting at least one ion species in an ion spectra including a signal acquisition circuit for detecting the ions in the spectra and generating output signals indicative thereof, a sequence and storage control circuit for tagging certain ones of the signals to be stored, a memory circuit for storing the output signals tagged by the sequence and storage control circuit, and a digital signal processor circuit receiving the tagged signals from the memory for summing the tagged data and generating an output signal indicative of a value of the ion species detected. A method for collecting the data is also disclosed. Further, the system of the present invention allows for easy storage of signals to be stored in a mass mapped buffer and addressed via a look-up table without requiring additional software to tag the data. Also, the system and method further provide for two banks of gain memory to update the amplifier gain setting without loss or corruption of data collection.

Time-of-flight mass spectrometer data acquisition system

A system intended for use in time-of-flight mass spectroscopy for detecting at least one ion species in an ion spectra including a signal acquisition circuit for detecting the ions in the spectra and generating output signals indicative thereof, a sequence and storage control circuit for tagging certain ones of the signals to be stored, a memory circuit for storing the output signals tagged by the sequence and storage control circuit, and a digital signal processor circuit receiving the tagged signals from the memory for summing the tagged data and generating an output signal indicative of a value of the ion species detected. A method for collecting the data is also disclosed.

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St. Joseph, MI, United States of America

Michael C Mason