Other

Trega Biosciences, Inc.

Lion Bioscience Ag

Isis Pharmaceuticals, Inc.

Michael C Griffith

John S Kiely

Michael Egholm

Peter Eigil Nielsen

Ole Buchardt

James M Coull

Beverly E Girten

Leif Hoejslet Christensen

Timothy Gahman

Amaresh Basu

Sandra R Slivka

Curtis C Hecht

Kim L Dueholm

Muthiah Manoharan

Michael J Green

Jesper Lohse

Kelly G Sprankle

Kevin Ross Holme

Christa Hamashin

Ming Qi

Karen J Watson-Straughan

Soren Holst Sonnechsen

James E Macdonald

Timothy C Gahman

A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

Peptide nucleic acid conjugates

Triamine derivative melanocortin receptor ligands and methods of using same

Methods for treating erectile dysfunction using tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands.

Treatment of erectile dysfunction using isoquinoline compound melanocortin receptor ligands

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.

Peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

Linked peptide nucleic acids

The invention relates to melanocortin receptor ligands and methods of using the ligands to alter or regulate the activity of a melanocortin receptor. The invention further relates to tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands and as agents for controlling cytokine-regulated physiologic processes and pathologies, and combinatorial libraries thereof.

Isoquinoline compound melanocortin receptor ligands and methods of using

The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

Isoquinoline derivatives and isoquinoline combinatorial libraries

Growing community of inventors

San Diego, CA, United States of America

Michael C Griffith