The Government of the United States of America As Represented by the Secretary of the Deptartment of Health and Human Services

Flexible Products Company

Other

The Johns Hopkins University

University of Utah Research Foundation

Baylor College of Medicine

Columbia University

University of Iowa Research Foundation

University of Illinois

Vanderbilt University

Aventis Pharma S.a.

Michael C Dean

Rando L Allikmets

Mark F Leppert

James R Lupski

Susan Elaine Bates

Philip M Smallwood

Jeremy Nathans

Nanda A Singh

Noah F Shroyer

Richard A Lewis

Hui Sun

Amir Rattner

Yixin Li

Kent L Anderson

James Brislin McMahon

Curtis J Henrich

Heidi R Bokesch

Robert W Robey

Suresh V Ambudkar

Suneet Shukla

Daniel P Brown

Nadya Tarasova

Kirk R Gustafson

Gregory S Hageman

Richard W Fuller

Ross Wilson

Anne Birgitte Unden

Peter G Zaphiropoulos

David J Leffell

Georgia Chenevix-Trench

Brandon Wainwright

Bernard Gerrard

Jeffrey Christiansen

Allen E Bale

Alisa Miriam Goldstein

Carol Leah Pressman

Susan Mary Shanley

Kylie Negus

Hong Lou

Albert M Gold

Heidi Eve Hahn

Kentaro Takada

Laura K Cartner

Carol Wicking

Mae R Gailani

Abirami Chidambaram

Igor Vorechovsky

Erika Holmberg-Lindstrom

Patrice Denefle

Catherine Prades

Marie Rosier

Vadim Gaponenko

Stephen James O'Brien

Sergey G Tarasov

Michael W Smith

Alla Ivanova

Joseph Kates

Ian McLeod Smyth

Brian Roger Clemons

Rune Carl-Magnus Toftgard

Susan Alana Gillies

Ian Mcleod Smyth

Gurp Ahluwalia

Gary Grunauer

Mary Carrington

Amy Ann Hutchinson

Isabelle Arnould

Antonio T Fojo

Rune C M Toftgard

Susan A Gilles

A table-like support placed within a pizza container between the pizza and the pizza container cover providing support for the pizza container cover to remain apart from the pizza, and includes a convenient and covered cutter cutting used to provide slices of a pizza pie. One embodiment includes within the support a removable section which reveals and provides user access to a circular cutter.

Pizza support table and combined cutter

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.

Method of inhibiting ABCG2 and related treatments

The invention provides a peptide or peptidomimetic that is derived from or based upon the amino acid sequence of the C-terminal &#x3b1;-helix or hypervariable region (HVR) or a Ras protein, a nucleic acid encoding the peptide or peptidomimetic, and methods employing the same.

Lipopeptide inhibitors of RAS oncoproteins

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): wherein R, R, R, X, X, X, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof.

Method of inhibiting ABCG2 and other treatment methods

Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and kits for use in these methods are also provided.

Variants in complement regulatory genes predict age-related macular degeneration

Disclosed is an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a Smoothened (SMO) protein, wherein the portion comprises an amino acid sequence of any of the intracellular loops of the SMO protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment, wherein the functional fragment comprises at least 7 contiguous amino acids of the intracellular loops, and wherein the functional fragment or functional variant inhibits proliferation of a diseased cell, or a fatty acid derivative thereof. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided. Methods of inhibiting proliferation of a diseased cell, treating or preventing cancer, treating a neoplasm or psoriasis, and inhibiting the expression of genes involved in the Hedgehog signaling pathway, thereby inhibiting the Hedgehog signaling pathway, are furthermore provided by the invention.

Smoothened polypeptides and methods of use

Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2, Pgp, or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering effective amounts of certain compounds to the mammal, for example, a compound of the formula (I): Formula (I), wherein R, R, R, X, X, X, a, and b are as described herein. Uses of these compounds in the preparation of a medicament are also disclosed. Also disclosed are compounds of formula (II), pharmaceutical compositions comprising such compounds and uses thereof. 

Botryllamides and method of inhibiting PGP in a mammal afflicted with cancer

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter

The invention is an improved lever drive arrangement for human powered machines. Independent levers are connected directly to a primary drive arrangement positioned behind the rider comprised of one-way clutch/s connected to a common shaft connected to a sprocket that drives by chain a series of two reductions called a secondary drive arrangement and a tertiary drive arrangement prior to engaging the final drive element. The positioning of the primary drive arrangement behind the rider better enables upright riding by a person and better enables increases in lever length thereby increasing mechanical advantage is possible for producing greater torque to drive larger or multiple reductions. The independent lever arrangement allows a rider to deviate from the traditional opposing circular or up and down cadence of the rider's limbs making possible a variety of limb pumping movements by one or more limbs.

Ratchet-action drive mechanism for human power

This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of thepatched (ptc) gene.

Basal cell carcinoma tumor suppressor protein

Methods of screening and diagnostics using ATP-binding cassette transporter

Growing community of inventors

Frederick, MD, United States of America

Michael C Dean