Trading Technologies International, Inc.

Vanderbilt University

Pablo, LLC

Michael C Burns

Harris C Brumfield

Scott F Singer

Jens-Uwe Schluetter

Gary Allan Kemp

Alex Gregory Waterson

Jason Phan

Qi Sun

Jason R Abbott

Gary Allen Kemp, Ii

Jens-Uwe Schuetter

Fred Monroe

Stephen W Fesik

James M Salovich

Steven F Borsand

David Babulak

Andrew Little

Steve W Fesik

J Phillip Kennedy

Pratiq Patel

The present invention relates to quinazoline compounds and compositions that modulate Ras signaling. Compounds and compositions of the present invention are useful in the treatment of cancers and other disease states associated with Ras dysfunction (e.g., Ras-associated autoimmune leukoproliferative disorder, or certain types of mitochondrial dysfunction) in a subject, for example a mammal or a human.

Quinazoline compounds as modulators of Ras signaling

Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.

Substituted benzimidazoles as modulators of Ras signaling

Tools for trading and monitoring a commodity on an electronic exchange using a graphical user interface and a user input device. The tools will aid the trader in determining the status, trends in the market, and the trader's position in the market.

Trading tools for electronic trading

A trading screen may include a plurality of next trade quantity regions that comprise a plurality of locations, each location being associated a price on a price axis. The quantities can be entered into the various locations in the next trade quantity regions and the entered quantities can be used as a parameter of a future trade order at the associated price level. The trading screen may also include a plurality of quantity entry regions that are displayed with respect to the price axis. The quantity entry columns may each include plurality of sub-regions or locations corresponding to different price levels in the price axis. The quantity entry columns may be used to specify next traded quantities that may be used in placing orders for tradeable objects.

Method and system for quantity entry

The present embodiments are provided to facilitate the automatic trading of spreads in a fast and accurate manner. One or more market data feeds that contain market information for tradeable objects are received at an exchange. A spread data feed is generated in response to the market data feeds and from one or more spread setting parameters, which can be entered by a user. The spread data feed is preferably displayed in a spread window as bid and ask quantities associated with an axis or scale of prices. The user can enter orders in the spread window and the legs will be automatically worked to achieve, or attempt to achieve, the spread. In addition, other tools disclosed herein may be utilized to assist the user in making such trades.

System and method for performing automatic spread trading

Orders are automatically sent to the market when certain user defined conditions are met. In particular, a trader can configure the trading application to automatically send orders for preset quantities at price levels with queues falling below a user-defined threshold. The length of queues may be measured in several ways, for example, the queue length could be measured by quantity at a given price level or the queue length could be measured by the number of orders at a given price level, or the queue length could be measured by a combination of quantity and orders. The present embodiments can more quickly recognize opportunities and send an order to take advantage of it than a trader can do manually. Other advantages and features are described herein.

System and method for automated order entry on short queues

Tools for trading and monitoring a commodity on an electronic exchange using a graphical user interface and a user input device. The tools will aid the trader in determining the status, trends in the market, and the trader's position in the market. Included is a system and method for displaying an indicator representing market information for a commodity in a display region of a graphical user interface. The system and method further includes linking a software application configured for computing a specific price to a second display region of the graphical user interface, and displaying a second indicator in a second display region of the graphical user interface. The second indicator moves relative to the price axis when the specific price changes.

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Chicago, IL, United States of America

Michael C Burns