Canada Packers Inc.

Michael C Attwell

Roberto A Vergottini

Peter Ziegler

Thomas F Massiah

Freeman Oswald Newson

A process for preparing a high-melting form of CDCA having a melting point of at least about 160.degree. C. is disclosed which comprises the steps of:

Process for preparing high-melting chenodeoxycholic acid

A method of isolating chenodeoxycholic acid from hog bile is provided, which comprises the steps of treating the hog bile under saponifying conditions separating the bile acids from the water-soluble constituents of the saponified bile; esterifying the bile acids to obtain a mixture of bile acid esters; isolating from the mixture of bile acid esters the hyodeoxycholic acid ester as its adduct with a compound selected from the group consisting of benzene and toluene; treating the remaining bile acid esters under acetylating conditions; isolating the hyocholic acid ester triacetate; isolating the chenodeoxycholic acid ester diacetate; treating the chenodeoxycholic acid ester diacetate under saponifying conditions; isolating the chenodeoxycholic acid thus obtained; and, optionally purifying the chenodeoxycholic acid. The method described yields chenodeoxycholic acid of exceedingly high purity, which may be used in the treatment of gallstones by their dissolution in vivo.

Chenodeoxycholic acid recovery process

Immunoglobulins for new-born piglets to provide them with antibodies effective against disease are administered as a dried particulate serum obtained from animal blood and having a reduced sodium chloride content. Such a serum is palatable to piglets and can be orally administered along with feed-stuffs.

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Islington, Canada

Michael C Attwell