Pfizer Corporation

Michael Butters

Alan John Pettman

Paul Vincent Fish

Trevor Jack Newbury

Richard Anthony Storey

Julie Ann Macrae

Michael Paul Fitzgerald

Anne Bruckner

Julie Ann Harrison

The invention provides a process for the preparation of a compound of the formula: or an acid addition or base salt thereof,wherein wherein R is as previously defined for a compound of the formula (I), with a compound of the formula: wherein Rand 'Het' are as previously defined for a compound of the formula (I) and X is chloro, bromo or iodo, in the presence of zinc, iodine and/or a Lewis acid and an aprotic organic solvent: said process being optionally followed by conversion of the compound of the formula (I) to an acid addition or base salt thereof.

Preparation of triazoles by organometallic addition to ketones and intermediates therefor

The invention provides a process for the preparation of a compound of the formula:or an acid addition or base salt thereof,

The invention described herein relates to a process for the preparation of (7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine (I), intermediates thereto and new forms and formulations thereof, including the zwitterion monohydrate of (I), suitable for pharmaceutical use.

(7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine

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Sandwich, United Kingdom

Michael Butters