Roche Diagnostics Operations, Inc.

Universitaet Bern

University of Twente

Westfalische Wilhems-Universitat Munster

Michael Busby

Luisa De Cola

Gion Calzaferri

Hans-Peter Josel

Zoran Popovic

Manuel Matthias Tsotsalas

Vinod Subramaniam

Christian Blum

A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.

Preparation of micro-porous crystals and conjugates thereof

The present invention discloses a method for the intercalation of a chromophore within channels of a zeolite L crystal. The intercalated chromophores exhibit J type aggregation of the chromophores within the channels of the zeolite L crystals. The invention discloses method parameters which lead to the J type aggregation of the chromophores within the channels of the zeolite L crystals. The J type aggregation of the chromophores affords unique florescent properties rendering the intercalated zeolite L crystals as a material for use in novel optoelectronic devices.

Method for intercalating chromophores into zeolite-L nanochannels and products thereof

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Münster, Germany

Michael Busby