Grifols, S.a.

Relypsa, Inc.

Vifor (international) Ltd.

Michael Burdick

Joann Hotta

Brett Buno

Dominique Charmot

Paul Mansky

Terri Journigan

Eric F Connor

Mingjun Liu

Han-Ting Chang

Jonathan Mills

Detlef Albrecht

Werner Strüver

Ramakrishnan Chidambaram

Sherin Halfon

I-Zu Huang

Eric Connor

Werner Struever

A method of purification of non-enveloped or pseudo-enveloped virus produced in vitro uses a composition with at least one detergent. A method of purification can use multiple detergents, and a method of determining the presence and/or level of a non-enveloped or pseudo-enveloped virus in a sample includes treating with at least one detergent.

Methods for purification of a virus produced in vitro and clearance assay for the virus

Polybrene as an additive in cell culture medium is used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. A cell culture medium containing polybrene is used for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.

Method for generating high-titer hepatitis E virus stocks and titration assay for hepatitis E virus

The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.

Linear polyol stabilized polyfluoroacrylate compositions

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Durham, NC, United States of America

Michael Burdick