Biomay Produktions- Und Handelsgesellschaft M.b.h.

Biomay Produktions- Und Handelsaktiengesellschaft

University of Rochester

Biomay Biotechnik Produktions Und Handelsgesellschaft M.b.h.

Michael Breitenbach

Dietrich Kraft

Rudolf Valenta

Otto Scheiner

Helmut Rumpold

Karin Pettenburger

Heimo Breiteneder

Christof Ebner

Michael Duchene

Klaus Richter

Fatima Ferreira

David S Goldfarb

Martin Himly

Birgit Simon-Nobbe

Peter Schneider

Ursula Denk

Verena Wally

Christian Radauer

Markus Teige

Edwin Engel

Recombinant materials, including DNA constructs, expression vectors, and host cells, and methods of identifying an environmental stimulus or a gene that alters the lifespan of an organism are identified. The recombinant DNA constructs include first and second chimeric genes that both encode substantially the same protein that is required for yeast replication, the first chimeric gene containing a promoter responsive to growth medium conditions and the second chimeric gene containing a promoter operable in mother cells but not daughter cells.

Materials and methods for identifying genes and/or agents that alter replicative lifespan

The invention relates to polypeptides made of mannitol-dehydrogenase ofandnucleic acids coding therefor and the use thereof in diagnosis and therapy.

Nucleic acid sequence and protein in addition to polypeptides coding for mannitol dehydrogenases or parts thereof and the production and use thereof in diagnosis and therapy

The invention relates to DNA molecules which code for the allergen Art v 1 or isoforms thereof, the sequence of the allergen, a method for the production of an Art v 1 molecule, a vector and a transformed host cell.

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The invention relates to a method by which expression cDNA clone banks are screened by means of IgE antibodies derived from the sera of allergic individuals, or by means of monoclonal or polyclonal antibodies. This type of screening is used for the detection of polynucleotides whose open-reading frames code for allergenically active proteins. These proteins are characterized in that their biological activity as allergens is equal to that of plant allergens occurring in nature.

Method for screening an expression cDNA clone bank for the detection of

The invention relates to a method by which expression cDNA clone banks are screened by means of IgE antibodies derived from the sera of allergic individuals, or by means of monoclonal or polyconal antibodies. This type of screening is used for the detection of polynucleotides whose open-reading frames code for allergenically active proteins. These proteins are characterized in that their biological activity as allergens is equal to that of plant allergens occurring in nature.

Allergens of alder pollen and applications thereof

The invention provides recombinant DNA molecules which code for polypeptides that exhibit the antigenicity of a P14 allergen of birch Betula verrucosa and other plants of the order Fagales, and for polypeptides comprising at least one epitope thereof, as well as nucleic acids which under stringent conditions hybridize with such DNA sequences or are derivable from such sequences by degeneracy of the genetic code. A method is provided that permits purification of P14 allergens or cross reactive allergens by means of binding to poly(L-proline). In addition, methods are described for making the proteins and polypeptides coded by these DNA molecules and their use in the diagnosis or therapy of diseases.

Method of production of birch pollen allergen P14

Birch pollen allergen P14 for diagnosis and therapy of allergic diseases

Growing community of inventors

Vienna, Austria

Michael Breitenbach