University of Pittsburgh

The United States Government As Represented by the Department of Veterans Affairs

Michael Brandt Steketee

Yolandi Van Der Merwe

Stephen Francis Badylak

William Richard Wagner

George S Hussey

Xinzhu Gu

Kia M Washington

Anne E Faust

Methods are disclosed herein for increasing retinal ganglion cell survival in a subject in need thereof. These methods include selecting a subject in need of increased retinal ganglion cell survival and administering a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix (MBVs) to the subject.

Ocular applications of matrix bound vesicles (MBVs)

Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided.

Devices and methods for local delivery of tacrolimus

Growing community of inventors

Wexford, PA, United States of America

Michael Brandt Steketee