Bionano Genomics, Inc.

Vortex Biosciences, Inc.

Michael Boyce-Jacino

Han Cao

Parikshit A Deshpande

Michael David Austin

Ming H Xiao

Bruce J Richardson

Kandaswamy Vijayan

Alexey Y Sharonov

Elodie Sollier

Michael Lee Kochersperger

James Che

Robert F Englert

Anna Passernig

Insang Choi

Anatasia Neddersen

Kuo-Wei Huang

Alexy Y Sharonov

Parikshit Deshpande

Michael Austin

Ming Xiao

Michael D Austin

Microfluidic chips and cartridges and systems that include such chips are disclosed. In some embodiments, the chips include a microfluidic channel disposed in a substrate with the channel comprising at least one expansion region. The channel is configured to generate a vortex within the at least one expansion region in response to fluid through the microfluidic channel to trap cells or particles. The substrate in which the channel is formed may be relatively rigid to resist deformation.

Microfluidic chips and cartridges and systems utilizing microfluidic chips and cartridges

Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.

Nanonozzle device arrays: their preparation and use for macromolecular analysis

Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as wen as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.

Methods of macromolecular analysis using nanochannel arrays

The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.

Polynucleotide mapping and sequencing

Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.

Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.

Methods and devices for single-molecule whole genome analysis

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Titusville, NJ, United States of America

Michael Boyce-Jacino