Hoffmann-La Roche Inc.

Michael Bos

Claus Riemer

Andrew Sleight

Thierry Godel

Jurgen Wichmann

Heinz Stadler

Walter Hunkeler

Ulrich Widmer

The present invention is concerned with compounds of formula I ##STR1## wherein Z, R.sup.1 and R.sup.2 are as defined herein, as well as their pharmaceutically acceptable salts as therapeutically active substances against central nervous system disorders and for the production of corresponding medicaments.

Use of sulfonamides

The present invention relates to novel compounds of the general formula ##STR1## wherein R.sup.1 is hydrogen;

Benzosulfone derivatives

The invention is concerned with the use of compounds of the general formula ##STR1## wherein R.sup.1 -R.sup.4 signify hydrogen, halogen, lower-alkyl, lower-alkoxy, aryl, benzyloxy, lower-alkoxy-lower-alkyl, lower-alkyl-sulphanyl, lower-alkyl-sulphanyl-lower-alkyl or R.sup.1 and R.sup.2 together signify the group --O--(CH.sub.2).sub.2 -- or --(CH.sub.2).sub.2 --O-- and

Method of treating diseases of the CNS

The present invention is concerned with compounds of formula ##STR1## wherein Z is a substituted indolyl group of formula ##STR2## R.sup.1 is hydrogen, amino, lower alkylamino, lower dialkylamino, lower alkyl, halogen, or trifluoromethyl;

The present invention is concerned with compounds of formula ##STR1## wherein Z is a substituted pyridyl group of formula ##STR2## R.sup.1 is hydrogen, amino, lower alkylamino, lower dialkylamino, lower alkyl, halogen, or trifluoromethyl;

The invention relates to tricyclic pyrrole derivatives useful as 5-HT selective agents of the formula ##STR1## wherein R.sup.1 to R.sup.4 are, independently, hydrogen, halogen, lower alkyl, phenyl, cycloalkyl or lower alkoxy and R.sup.2 additionally is lower alkoxycarbonyl, acyloxy or mesyloxy;

Tricyclic pyrrole derivatives useful as 5-HT selective agents

The invention releates to indole derivatives of the formula ##STR1## wherein R.sup.1 to R.sup.4 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl or trifluoromethyl, R.sup.5 and R.sup.6 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl, trifluoromethyl, hydroxy or lower-alkoxy and R.sup.7 is hydrogen or lower-alkyl, and pharmaceutically acceptable acid addition salts thereof. The compounds of formula I bind to serotonin receptors and are therefore useful in the treatment and/or prevention of central nervous system disorders, such as depression.

Growing community of inventors

Rheinfelden, Switzerland

Michael Bos