Degussa Aktiengesellschaft

Evonik Degussa Gmbh

Degussa - Huls Ag

Michael Binder

Walter Pfefferle

Georg Thierbach

Dieter Greissinger

Klaus Huthmacher

Brigitte Bathe

Bettina Moeckel

Thomas Hermann

Joern Kalinowski

Alfred Puehler

Klaus-Erich Uffmann

Christian Rueckert

Mike Farwick

Ulrich Becker

Matthias Moll

Alexander Moeller

IIona Walger

Christoph Weckbecker

Maria-Regina Kula

Heinz Friedrich

Jörn Kalinowski

Alfred Pühler

Stefan Verseck

Steffen Osswald

Andreas Tauch

Uta Deiting

Konrad Odendahl

Achim Marx

Caroline Kreutzer

Natalie Schischka

Bettina Möckel

Jennifer Brehme

Klaus Erich Uffmann

Michael Buchholz

Stefan Hans

Thoams Hermann

The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

Coryneform host-vector systems comprising a chromosomal ALR gene which is attenuated or eliminated and methods of using

Nucleotide sequences encoding alanine racemase from coryneform

The invention relates to apolynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein PK which activates this enzyme and of a cobalt transporter, to transformed microorganisms in which the nucleotide sequences encoding these proteins are present in increased quantity, and to the use of the transformed microorganisms for preparing amides from nitriles.

Rhodococcus nitrile hydratase

The invention relates to sulfur-containing animal-feed additives produced from fermentation liquors, and to processes for their production.

Sulfur-containing animal-feed additives

The invention relates to apolynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K which activates this enzyme and of a cobalt transporter, to transformed microorganisms in which the nucleotide sequences encoding these proteins are present in increased quantity, and to the use of the transformed microorganisms for preparing amides from nitriles.

An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of

Nucleotide sequence which code for the metH gene

Isolated polynucleotide from Corynebacterium encoding a homocysteine methyltransferase

An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of

Nucleotide sequences which code for the rpsL gene

The present invention relates lo an isolated polynucleotide fromcomprising a polynucleotide sequence chosen from the group c insisting of (a) a polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO: 2; (b) a polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO: 2; (c) a polynucleotide which is complementary to the polynucleotides of(a) or (b), and (d) a polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the sigE gene is present in enhanced form, and the use of polynucleotides which comprise the sequence according to the invention as hybridization probes.

Methods of making L-amino acids in coryneform using the sigE gene

Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.

Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes

The present invention relates to isolated polynucleotides from encoding proteins of the transcription activator (MetR) and O-succinylhomoserine sulfhydrylase (MetZ). The invention also relates to producing L-amino acids, particularly methionine, in coryneform cells having attenuated metR and metZ genes.

Nucleotide sequences encoding o-succinylhomoserine sulfhydrylase

The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of preparing L-amino acids.

Nucleotide sequences which code for the metY gene

The present invention relates to polynucleotides corresponding to the rpoB gene and which encode the &bgr;-subunit of RNA polymerase B, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having activity of the &bgr;-subunit of RNA polymerase B.

Nucleotide sequences which code for the rpoB gene

Nucleotide sequences which code for the sahH gene

A composition including at least one of D-pantothenic acid and a salt of D-panthothenic acid, greater than 50 percent of non-biomass constituents of a D-pantothenic fermentation liquor, and 0 to 100% of the biomass from D-pantothenic fermentation liquor wherein composition is a solid, pourable composition in the form of particles.

Pourable feed additives containing D-pantothenic acid and/or salts thereof, and process for their preparation

Growing community of inventors

Steinhagen, Germany

Michael Binder