Palo Alto Research Center Inc.

Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Siemens Healthcare Gmbh

Michael Bassler

Peter Kiesel

Oliver Schmidt

Noble Marshall Johnson

Markus Beck

Joerg Martini

Richard H Bruce

Alex N Hegyi

Uma Srinivasan

Jeffrey N Roe

Jurgen Hans Daniel

Alan G Bell

Marshall Bern

Malte Huck

Tobias Buergel

Patrick Yasuo Maeda

Klaus Stefan Drese

Rainer Gransee

Manfred Ruehrig

Stephan Quint

Daniel Latta

Almuth Hoffmann

Vishnu Vatheriparambil Mohandas

Karin Potje-Kamloth

Knut Welzel

Jergens Hans Daniel

Matthias Besold

Tobias Burgel

A filter system is for the local attenuation of X-radiation. In an embodiment, the filter system includes a filter device, arranged in a beam path of an X-ray apparatus and including a channel arrangement, the channel arrangement including a multiplicity of channel sections extending in parallel on a plane; a supply device to provide a 2-phase fluid flow containing drops of an absorber liquid, to absorb X-radiation and a carrier liquid transparent to X-radiation; and a sorting section, including an input connected to the supply device, a first output connected to the channel arrangement, a second output, and a deflection device to direct individual drops of the absorber liquid to the first output or the second output.

Filter system for the local attenuation of X-radiation, X-ray apparatus and method for locally changing the intensity of X-radiation

Embodiments relate to a device (), a method and a computer program for providing information on at least one sequence, wherein the at least one sequence describes temporally successive signal states, comprising a device (), a method and a computer program for a cytometer () for providing information on one or several cells in a medium in a channel and comprising a cytometer (). The device () comprises an interface (), which is configured to receive information on a number of the signal states. The device () a computational module () which is configured to generate a plurality of possible sequences based on the information on the number of the signal states. The computational module () is further configured to calculate for at least a subset of the possible sequences correlation functions between a sequence and at least a temporal scaling of the sequence, wherein a correlation function includes a main lobe and one or several side lobes. The computational module () is further configured to determine the at least one sequence based on the correlation functions, wherein the order of the signal states within the at least one sequence is selected such that a side lobe in a correlation function of the sequence comprising the at least one temporal scaling of the sequence is reduced as compared to a side lobe which may maximally be acquired in a correlation function by different arrangements of the signal states in the sequence, and to determine the information on the at least one sequence based on the at least one sequence and provide the same via the interface ().

Devices, cytometers, methods and computer program for providing information on at least one sequence

A sensor for detecting a liquid in a fluid channel of a microfluidic component and to a microfluidic component having such a sensor. The sensor includes an electrode arrangement having a transmitting electrode, a receiving electrode and a first shielding electrode, which are arranged in a coplanar manner on a plane and can be positioned above or below, adjacent to the fluid channel, wherein the transmitting electrode and the receiving electrode are capacitively coupled in that they each have an adjacently arranged edge having a dielectric therebetween. A method for detecting a liquid in a fluid channel of a microfluidic component having the steps: applying an alternating voltage to the transmitting electrode, coupling the alternating voltage into the receiving electrode, tapping an alternating current or alternating voltage signal on the receiving electrode, extracting extreme values from the tapped alternating current or alternating voltage signal, and assigning the extreme values to the position of a liquid front.

Sensor for detecting a liquid in a fluid channel

A fluidic system having a first volume, a second volume and a membrane geometrically separating the two volumes, which has an open-pore microstructure for the passage of a first medium and a second medium. There is a contact angle (&#x398;) between the interface of the media and the pore surface. A first electrical field in the region of the membrane and a first electromagnetic radiation and a first heating of the membrane define a first state (Z), in which the membrane is not wetted or is less wetted by the first medium and is more heavily wetted by the second medium such that a first contact angle &#x398;&#x3e;90&#xb0; is formed between the pore surface and the interface. The first medium and the second medium and the pore surface have a surface energy of which at least one surface energy can be reversibly changed in such a way that a second contact angle &#x398;&#x3c;&#x398;occurs between the pore surface and the interface in a second state (Z).

Fluidic system, use, and method for operating the same

A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the 'blinking' of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.

Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity

A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.

Analyzers with time variation based on color-coded spatial modulation

An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.

Controlling transfer of objects affecting optical characteristics

A method is provided for extracting the position of a particle, e.g., a moving or stationary particle that is excited or is emitting light. The method includes, among other steps, detecting and recording a signal based on, for example, the movement of the particle, a correlation step to eliminate noise and to create a transformed signal, a matching or fitting step to match the transformed signal to a fit function and an extracting or determining step to determine the position of the particle from the fit function. In one form, at least two particle positions are detected so that the distance between the subject particles can be determined.

Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances

An embodiment is a display unit. The display unit includes a substrate layer, a layer of colored fluid on the substrate layer, and a transparent actuator element on the layer of the colored fluid. The layer of colored fluid has a thickness and a color. The transparent actuator element modulates the thickness of the colored fluid upon activated by a force such that the colored fluid is changed from a first state to a second state or vice versa. The modulated thickness provides a variable optical density of the colored fluid.

Modulating thickness of colored fluid in color display

An analyzer includes a flow cell having a flow channel through which a sample passes. A light source excites at least a first particle type in the sample in one or more excitation region(s), and a detector detects light emitted by the excited particle. A spatial filter defines detection regions, wherein light emitted by the particle is transmitted to the detector, and interspersed shielded regions, wherein such light is at least partially blocked from reaching the detector. The light emitted by the excited particle has a response time &#x3c4;, and the sample may also contain a component that is excited by the light source and that has a response time &#x3c4;. The excitation region(s) and the detection regions are arranged to provide a time delay between excitation and detection, the time delay tailored to isolate light emitted by the first particle from light emitted by the component.

Particle analyzer with spatial modulation and long lifetime bioprobes

A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences.

A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. One or more mask arrangements can be configured to receive the emanating light and in response provide encoded emanating light.

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Menlo Park, CA, United States of America

Michael Bassler