Abbott Laboratories Corporation

Michael B O'Connell

Robert G Parsons

Bob O Basore

Kevin J Forney

Paul J Ropella

Andrew J Muetterties

Edward S Tripp

Kenneth P English

Stanley E Micek, Iii

A device for performing agglutination immunoassay reactions and the like is disclosed. The device includes a first hydrophilic layer, a second liquid-occlusive layer parallel to and overlying the first layer, and a third layer parallel to and overlying the second layer. The third layer has a transparent opening for observing particles. The second layer is interposed between and in adherent relationship to the first and third layers. The second layer has at least one slot defining a channel for directing liquid conducted by capillary action through the chamber defined in conjunction with the first and third layers. This chamber has a proximate zone and a distal zone. The geometry of the chamber is modified to provide preferably outwardly diverging walls and provide a flowpath having different rates of flow per unit area along the paths. This arrangement of different paths in the chamber allows agglutination reactions in the chamber to result in the formation of a non-random pattern of aggregated particles in the distal zone of the chamber. Such a non-random pattern is more readily observable than a random pattern of aggregated particles.

Agglutination reaction device having geometrically modified chambers

An improved device for performing agglutination reactions is disclosed. The device has at least one chamber with a proximate zone and a distal zone in which chamber agglutination reactions can be performed. The improvement comprises utilization in the device of a layer of liquid absorbent material for controlling overall rate of liquid flow through the chamber. The layer of liquid absorbent material is selectively impregnated with a substance to form an impregnated region and a non-impregnated region wherein the non-impregnated region is liquid absorbent and the impregnated region is liquid-occlusive. A portion of the non-impregnated region is positioned within the distal zone of the chamber so that the non-impregnated region is in liquid communication with that zone.

Agglutination reaction device utilizing selectively impregnated porous

A diagnostic testing device is disclosed. The testing device includes a base member and a cover member which defines an opening for the reception of a liquid specimen. A distribution wheel delivers portions of the specimen to antibiotic units which are circumferentially spaced. Indicator units are in communication with the cover member. A delivery cylinder extends upwardly from each of the antibiotic units toward a respective one of the indicator units. Relative vertical movement between the delivery cylinder and the indicator unit places the cylinder and the indicator unit into an engaging relationship. A change in coloration at an indicator unit indicates a positive reaction.

Diagnostic testing device

Growing community of inventors

Waukegan, IL, United States of America

Michael B O'Connell