Cedars-Sinai Medical Center

University of Pittsburgh

Michael B Gorin

Anthony B Nesburn

M Cristina Kenney

Ezra Maguen

Marvin Martinez

Robert Ferrell

Yvette P Conley

Johanna Jakobsdottir

Daniel E Weeks

Tammy S Mah-Fraser

Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of ARM in an individual that comprises identification of allelic variations in PLEKHA1 and/or LOC387715. Related apparatus, such as an array, are identified as being useful in implementing those methods.

Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26

A method of screening for retinal disease including directing a first light at a first portion of the retina, directing a second light at a second portion of the retina, measuring a first pupillary response of the eye as a result of the first light and a second pupillary response as a result of the second light, and generating an indication of a severity level of the retinal disease using the first pupillary response and the second pupillary response. Also, an apparatus that implements this method including a light source for directing a first light at a first retinal portion and a second light at a second retinal portion, a pupil measuring device for measuring the pupillary response of the eye as a result of the first light and second light, a processor in electronic communication with the pupil measuring device, and a memory in electronic communication with the processor.

Method and apparatus for screening for retinopathy

A method for molecularly crosslinking amino acid-containing polymers by photoactivating chemical crosslinkers which have been combined with the polymers. Collagen crosslinked by this method can be used as a bioadhesive for sutureless closures of the skin and eye or as a superhydrated material for contact lenses, moist bandage contact lens, lens or corneal implant material, or as a drug delivery mechanism.

Method of crosslinking amino acid-containing polymers using

A method for molecularly crosslinking amino acid containing polymers by photoactivating chemical crosslinkers which have been combined with the polymers. Collagen crosslinked by this method can be used as a bioadhesive for sutureless closures of the skin and eye or as a superhydrated material for contact lenses, moist bandage contact lens, lens or corneal implant material, or as a drug delivery mechanism.

Method of crosslinking amino acid containing polymers using

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Pittsburgh, PA, United States of America

Michael B Gorin