Pom Wonderful, LLC

Stewart and Lynda Resnick Revocable Trust

Technion Research & Development Foundation Limited

Lycored Natural Products Industries Ltd.

Ready-made 37 Ltd.

Steward and Lynda Resnick Revocable Trust

Michael Aviram

Leslie Dornfeld

Bianca Fuhrman

Zeev Gross

Zohar Nir

Adi Haber

Morris Zelkha

Harley Liker

Atif Mahammed

Raymond Coleman

Luba Cohen

Jeorg Gruenwald

Embodiments of the invention relate to methods of treatment a cardiovascular disease in a patient comprising administering an effective amount of a statin or a pharmaceutically acceptable salt thereof in combination with an effective amount of a transition metal complex of a corrole, an optically active isomer thereof or a pharmaceutically acceptable salt thereof. Further embodiments refer to pharmaceutical compositions comprising a statin and a corrole. Optionally, the corrole has a structure: wherein;M is a transition metal selected from the group consisting of Mn, Fe, Ru, Co, V, Cr, and Cu and R, R, R, X, X, XX; E, E, Eand Eare each defined as in the specification.

Combinations of corroles and statins

Methods of using pomegranate extracts of the present invention for treating patients with atherosclerosis, or increased intima-media thickness of an artery, are provided. The methods comprise the step of administering to the patient a composition comprising a therapeutically effective amount of an extract from pomegranate. The methods of the present invention may also be used to decrease the incidence of stroke or heart attack in a patient.

Compositions and methods using pomegranate extracts

One or more embodiments of the invention are directed to methods of using pomegranate extracts for treating diabetes related atherosclerotic complications in humans. The methods comprise the step of administering to the patients a composition comprising a therapeutically effective amount of an extract from pomegranate.

Methods and pomegranate extract composition for treating diabetes related atherosclerotic complications in humans

A pomegranate beverage including a pomegranate juice component prepared by crushing and squeezing whole fruits of pomegranate including inner and outer peels and seeds to yield a juice component and an insoluble by-product component, where the juice component separated from the insoluble by-product component to obtain the pomegranate juice component, and an amount of a pomegranate extract component including at least 30 to 3000 &#x3bc;mols of polyphenols, where the beverage is prepared by a process including re-suspending the insoluble by-product component in an aqueous medium, mixing the re-suspended insoluble by-product component and the aqueous medium, and separating an aqueous extract from the insoluble by-product component to obtain the pomegranate extract component, where the aqueous extract includes polyphenols resulting from the insoluble by-product component.

Transition metal complexes of amphiphilic/bipolar corroles, optically active isomers or pharmaceutically acceptable salts thereof are useful for prevention of a cardiovascular disease or disorder in a subject susceptible to develop such a cardiovascular disease or disorder.

Transition metal complexes of corroles for preventing cardiovascular diseases or disorders

Methods of using pomegranate extracts for treating diabetes related atherosclerotic complications in humans

Various processes for producing an extract containing phytochemicals from pomegranates are disclosed. The processes generally comprise providing pomegranate solids, such as the pericarp, inner membrane and seeds; creating a mixture comprising the pomegranate solids in an aqueous solution; adding enzymes to the mixture in an amount sufficient to at least partially degrade the pomegranate solids; heating the mixture to a temperature that permits the maximum rate of catalysis of the enzyme; maintaining the temperature of the heated mixture for a time sufficient to allow at least partial degradation of the pomegranate solids; and removing residual insoluble solid materials from the mixture. Compositions containing the extract may be used as a food product, beverage, pharmaceutical preparations, nutritional supplements, vitamin supplements, food additives, and food supplements. The compositions may also be used for preventing or ameliorating disease conditions by administering an effective amount of the composition to a subject in need thereof.

Methods of making pomegranate compounds for the treatment of erectile dysfunction

Methods of using pomegranate extracts for causing regression in lesions due to arteriosclerosis in humans

Process for producing a therapeutically effective amount of an extract from pomegranate and compositions relating to same

Methods for treating hypertension in a subject using pomegranate extracts

Described are a plurality of risk factors that may be treated and conditions that may be prevented and treated by administering to a patient a preparation containing a licorice extract, which is water insoluble and free from glycyrrhizinic acid. Risk factors that may be lowered include hypertension, high blood glucose concentration, LDL susceptibility to retention, LDL susceptibility to aggregation, blood total cholesterol and LDL levels, and blood tryglicerides and VLDL concentration. Conditions and diseases that may be treated according to the invention include aterosclerotic diseases, hypertension, cardiovascular diseases, chronic renal failure, carotid artery stenosis, coronary heart diseases, hypercholesterolemia, and hypertriglyceridemia.

Licorice extract for use as a medicament

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Kiriat-Haim, Israel

Michael Aviram