Smithkline Beecham Corporation

Other

Affinium Pharmaceuticals, Inc.

The Brigham and Women's Hospital, Inc.

Virus Research Institute

Michael Arthur Lonetto

Richard Oakley Nicholas

John Edward Hodgson

Michael Terence Black

Martin M Rosenberg

Julie M Pratt

Patrick Vernon Warren

Judith M Ward

Raymond Winfield Reichard

David Justin Charles Knowles

Richard Lloyd Warren

David Justin Knowles

Leslie Marie Palmer

Martin Karl Russel Burnham

Martin Karl Burnham

Robert King Stodola

Jason Craig Fedon

Christopher Michael Traini

David John Holmes

Magdalena Zalacain

Sanjoy Biswas

Anna Lisa Kosmatka

John E Hodgson

Min Wang

Deborah Dee Jaworski

Martin Karl Russell Burnham

Robert L Deresiewicz

Adrian M Lowe

David T Beattie

Lisa Kathleen Shilling

Joanna Lynn Fueyo

Nicola Gail Wallis

James Raymond Brown

Christine Marie Debouck

Jeffrey L Mooney

Pan Fong Chan

Phillip N Zarfos

Stephanie Van Horn

Yi Yi Zhong

Daniel Robert Sylvester

Robert H Reid

Karen Anne Ingraham

Alison Francis Chalker

Damien McDevitt

David William Holden

Richard L Warren, Jr

Jennifer E Ray

Andrea Marra

Gee W Lau

Sauli J Haataja

Jun Yu

Yi Y Zhong

Michael Terance Black

Jamie M Pratt

Raymond Winfield Riechard

Robert H Reid, Jr

Richard Oakly Nicholas

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.

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The invention provides Defl polypeptides and DNA (RNA) encoding Defl polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Defl polypeptides to screen for antibacterial compounds.

Defl

The invention provides lacR polypeptides and polynucleotides encoding lacR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacR polypeptides to screen for antibacterial compounds.

lacR from Streptococcus pneumoniae

The invention provides fucose kinase promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.

Fucose kinase

The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.

ribB

The invention provides rnc polypeptides and DNA (RNA) encoding rnc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing rnc polypeptides to screen for antibacterial compounds.

Ribonuclease III from Streptococcus pneumoniae

The invention provides Def1 polypeptides and DNA (RNA) encoding Def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Def1 polypeptides to screen for antibacterial compounds.

Def1

The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.

MurD

The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.

Prokaryotic polynucleotides polypeptides and their uses

The invention provides Glutamine Transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Glutamine Transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glutamine Transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.

Polynucleotides encoding a novel glutamine transport ATP-binding protein

The invention provides RncS polypeptides and DNA (RNA) encoding RncS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RncS polypeptides to screen for antibacterial compounds.

Polynucleotides encoding a ribonuclease s

The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai polypeptides to screen for antibacterial compounds.

Growing community of inventors

Collegeville, PA, United States of America

Michael Arthur Lonetto