Boston Scientific Scimed, Inc.

Cardiac Pacemakers, Inc.

Aspen Research Corporation

Michael Arney

Robert Warner

Liliana Atanasoska

Scott Schewe

Jan Weber

Huisun Wang

Aiden Flanagan

Kurt E Heikkila

Daniel James Horn

Joseph T Delaney, Jr

Andrew L De Kock

John B Blix

Victor Leo Schoenle

James Q Feng

David A Durand

James Lee Shippy, Iii

Tom Holman

Steven M Spencer

James Edward Fairman

Russell John Pylkki

Greg Olson

Frank Genovese

Shankar Godavarti

Jesse Christian Thiesen-Toupal

Douglas E Wilken

The disclosure pertains to hemostatic compositions comprising a plurality of nonwoven fibers disposed in a rapidly soluble solid matrix and methods of making and using the same. The compositions may also comprise one or more therapeutic agents.

Hemostatic compositions and methods of making and using same

Described is a guide catheter for guiding other medical devices into or through a body lumen, comprising: a polymeric, tubular inner liner having a textured inner surface; and, a polymeric jacket bonded to an exterior of the inner liner; wherein the texture of the inner surface of the inner liner reduces the coefficient of friction between the inner liner and the other medical devices.

Medical device with textured surface

Medical devices and related methods are disclosed.

Medical devices

In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.

Drug eluting medical devices having porous layers

Medical devices and related methods are disclosed. In some embodiments, a method of manufacturing a medical device or a medical device component includes contacting a non-fluid first member and a second member, the first member comprising a first polymer and an alignable material different from the first polymer; aligning the alignable material; and bonding the first and second members together.

Implantable or insertable medical devices are described, which include one or more polymeric regions and one or more therapeutic agents. The polymeric regions, which regulate the release of one or more therapeutic agent from the medical device, contain copolymer molecules, each of which includes one or more soft segments and one or more uniform hard segments (e.g., polyamide segments that do not vary in length from molecule to molecule, among others).

Medical devices for therapeutic agent delivery with polymeric regions that contain copolymers having both soft segments and uniform length hard segments

Coating compositions and coatings for medical devices formed from the coating compositions that include a catalyst in a support polymer, where the support polymer helps to support and retain the catalyst in the coating on the medical device. The catalyst in the support polymer can act to chemically bond specific compounds migrating from a body of the medical device formed from a polymer to at least one of the polymer and/or other specific compounds migrating from the body of the medical device.

Polymer coatings with catalyst for medical devices

A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.

Self-buffering medical implants

Methods of manufacturing drug-coated medical devices having a porous coatings thereon. The pores are created by solid particle additives added to a mixture comprising a solvent, a drug, and a polymer to create a suspension, which is applied to the medical device. The method includes adding a surfactant to the mixture to prevent or decrease flocculation of the solid particle additives. Another method is provided that includes spraying a suspension on a medical device that comprises solid particle additives, a drug, and a polymer and analyzing the distribution of the solid particle additives in the suspension.

Method of manufacturing a medical device having a porous coating thereon

Medical devices including a proximal tubular member, a distal tubular member, and an intermediate tubular member connecting the proximal tubular member to the distal tubular member, and related methods.

Medical devices and related systems and methods

An improved transparent optical member, preferably a glass sheet, comprising a nanostructure layer with an enhanced geometry and a balance of chemical (hydrophobic and hydrophilic) characteristics can be formed on a surface. The geometry and chemistry of the layer combine to obtain improved washability. The layer can be manufactured by forming a layer comprising a silicon compound coating, including a silicon oxide coating, a silicon carbide coating, a silicon nitride coating or mixtures thereof. The coating can have a having a thickness of about 1 to 100 nm (10 meter). The layer has a preferred roughens from a random or ordered array of structure. The layer can be doped with di tri or polyvalent metal compounds. Such coatings have been found to have increased washability and such coatings have been found to preferentially bind to aqueous solutions applied to the glass. The hydrophilicity and preferential binding to aqueous solutions (wetability) tends to displace any soil deposited or contacted with the glass surface. As a result, the glass tends to associate with aqueous solutions and to disassociate soil when contacted with aqueous solutions substantially increasing the ease of cleaning the glass surface using water, aqueous cleaning solutions, etc.

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Minneapolis, MN, United States of America

Michael Arney