Axion Biosystems, Inc.

Michael Antony Clements

James David Ross

Isaac Perry Clements

Amanda Jervis Preyer

Edgar A Brown

Andrew Willsie

Daniel Christopher Millard

Robert Dixon Grier, Jr

Thomas J O'brien

Denise Danielle Sullivan

A scalable, real-time, label-free, electrode- or optical-based cell monitoring system for integration into a cell culture incubator is described herein. An example system includes (1) cell culture consumables with integrated electrodes and/or optics for growing and monitoring cells, (2) incubator trays for consumable organization and recording, and (3) a system console, external to the incubator, for connecting multiple incubator trays. Without perturbing the cell culture, the system is capable of monitoring multiple culture attributes for each cell culture consumable simultaneously. These attributes can include, but are not limited to, cell growth, proliferation, morphology, media pH, or media oxygen. The system can support multiple trays, which permits monitoring dozens to hundreds of consumables simultaneously, including a mixture of consumables of various sizes. In addition to monitoring adherent cells, the disclosed technology can be readily adapted for monitoring of cell suspensions.

Devices and systems with integrated electrodes or optical elements for monitoring cell cultures and related methods

Growing community of inventors

Johns Creek, GA, United States of America

Michael Antony Clements