Uchicago Argonne, LLC

Michael Alexander Brown

Jerry A Nolen, Jr

David Alan Rotsch

Sergey D Chemerisov

Artem V Gelis

Jeongseog Song

Walter F Henning

James L Bailey

David A Ehst

Ronald T Kmak

Peter Tkac

Nicholas A Smith

Amanda J Youker

David J Bettinardi

Sergey A Chemerisov

James J Grudzinski

The invention provides a method for generating medical isotopes, the method comprising contacting a primary radiation beam with a converter for a time sufficient to produce a secondary beam of gamma particles, and contacting the beam of gamma particles to a target, where the cross section dimension of the beam of gamma particles is similar to the cross section dimension of the target. Both the converter and target are small in diameter and very closely spaced. Also provided is a system for producing medical isotopes, the device comprising a housing having a first upstream end and a second downstream end, a radiotransparent channel (collimator) with a first upstream end and a downstream end, wherein the upstream end is adapted to receive a radiation beam, a target positioned downstream of the downstream end of the channel and coaxially aligned with the channel, wherein the target has a cross section that is similar to the cross section of the channel.

Compact assembly for production of medical isotopes via photonuclear reactions

A method for separating a parent isotope from a daughter isotope is provided, the method comprising supplying irradiated target; dissolving the irradiated target; treating the dissolved irradiated target to a precipitation step to form a first solid phase of the parent isotope and a first liquid phase of the daughter isotope; filtering the first liquid phase of daughter isotope to create a first purified fraction of the daughter isotope to create a second solid phase of the parent isotope and a second liquid phase of the daughter isotope; and filtering the second liquid phase to create a second liquid fraction of the daughter isotope. The process can be repeated until theMo is exhausted and the enriched target materialMo orMo can be easily re-used.

Technetium-99M generator for enriched molybdenum

A system for producing and harvesting radioisotopes is provided, the system having a converter housing defining a first beam window; a converter carrier and cartridge in slidable communication with the converter housing; a target housing positioned downstream from the converter housing, the target housing defining a second beam window; and a target carrier in slidable communication with the target housing.

Radioisotope target station

A method for obtainingAC fromRa having the steps of assembling a column having an inorganic stationary phase; priming the column to immobilizeRaRa and natural decay products therefrom; immobilizing theRa,Ra,Ra, and natural decay products therefrom onto a stationary phase within the column; and eluting the column containing theRa with an aqueous sulfate solution to obtain a milking effluent that containsAC. Also provided is a method for obtaining pureAC from its isotope parents, the method comprising assembling a column having a stationary phase comprising an inorganic material; priming the column with the isotope parents to immobilizeAc, and natural decay products ofAC; immobilizing theAc, and natural decay products therefrom onto the stationary phase within the columnRa,Ra,Ra; and eluting the column containing theAC to obtain an effluent that contains the isotope parents.

System and method for collecting and isolating radiosotopes

The invention provides a method for isolating medical isotopes, the method having the steps of dissolving titanium nuclear targets to create a solution; contacting the solution with a resin so as to retain the isotopes on the resin and generate an eluent containing titanium; contacting the isotope-containing resin with acid of a first concentration to remove impurities from the resin; and contacting the isotope-containing resin with an acid of a second concentration to remove isotope from the resin.

Process for the separation and purification of medical isotopes

The invention provides a method for isolating scandium, the method having the steps of dissolving titanium nuclear targets to create a solution; contacting the solution with a resin so as to retain scandium on the resin and generate an eluent containing titanium; contacting the scandium-containing resin with acid of a first concentration to remove impurities from the resin; and contacting the scandium-containing resin with an acid of a second concentration to remove scandium from the resin.

Process for the separation and purification of scandium medical isotopes

The invention provides a method for extracting transition metals, the method comprising supplying a feedstream containing transition metal, mixing the feedstream with nitric acid for a time and at a concentration sufficient to form an aqueous phase containing the transition metal, combining the aqueous phase with organic extractant phase for a time and at a concentration sufficient to cause the transition metal to reside within the organic extractant phase, and combining the transition metal-containing organic extractant phase with an hydroxamic acid-containing aqueous phase at a concentration and for a time sufficient to cause the transition metal to reside in the hydroxamic acid-containing aqueous phase.

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Chicago, IL, United States of America

Michael Alexander Brown