Fluidigm Corporation

Grace Bio-labs, Inc.

Michael Albert Shultz

Jason A A West

Florian Gene Bell

Jennipher Lyn Grudzien

Charles M McGrath

Kyle W Hukari

Michael C DeRenzi

Nikolas M Isely

Richard Milson

An approach is described that combines distinct properties of a specialized porous nitrocellulose film (PNC) with quantum nanoparticles to create an improved assay and detection sensitivity, permitting the development of a camera-based imaging system for fluorescent detection of macromolecules in microarray format. The two properties of PNC that facilitate the approach are an extraordinarily high binding capacity and a newly observed internal scattering of light. Quantum nanoparticles complement these PNC properties by providing a higher level of emitted light than the fluorescent dyes in common microarray use. Overall, the approach allows for instrument cost savings, reduced imaging time, and the ability to remotely image.

Protein microarray assay imager

Provided are cartridges and systems for effecting automated extraction, isolation, and purification of cellular components&#x2014;such as nucleic acids&#x2014;from a cellular sample in assay-ready form. Also provided are related methods of effecting such sample processing.

Automated cellular material preparation

Growing community of inventors

Bend, OR, United States of America

Michael Albert Shultz