Pfizer Corporation

Amgen Fremont Inc.

Other

Bristol-myers Squibb Compnay

Michael Aidan North

Xin Jiang

Dana Dan Hu-Lowe

Jianying Wang

James A Thomson

Vahe Bedian

Shannon Marie Karlicek

Grant Raymond Wickman

Jingchuan Zhang

Karin Kristina Amundson

Haichun Huang

Brigitte Devaux

Peter Brams

Steven Lee Bender

Haibin Chen

Kristopher Toy

Mark Yamanaka

Dawn M Tanamachi

Lan Yang

Sirid-Aimee Kellermann

Gerald Fries Casperson

Gang Li

Tim Sproul

Shelley Sims Belouski

Grant Wickman

Sirid Aimee Kellerman

Sirid-Aimée Kellerman

Shelly Sims Belouski

Dehlia Dodd

Tim W Sproul

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like, kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Human monoclonal antibodies to activin receptor-like kinase-1

A traveling sprinkler system comprising: a sphere shaped surface; at least one wheel over a circumference of the sphere shaped surface, where the at least one wheel divides the sphere into a first half and a second half; a plurality of holes on both the first half and the second half of the sphere shaped surface; a water hose receptacle, where the water hose receptacle receives a flow of water from a water hose; and wheel gears within the sphere, where the flow of water transfers over the wheel gears to enable the movement of the at least one wheel and the flow of water transfers through the plurality of holes creating a sprinkling action.

Ball shaped water sprinkler system

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin &#x3b1;5&#x3b2;1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-&#x3b1;5&#x3b2;1 antibodies or antigen binding portions thereof described herein.

Alpha5-beta1 antibodies and their uses

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Alpha 5-beta 1 antibodies and their uses

The present invention discloses an air-entrainment mechanism for carbureted engine. The mechanism includes a plunger valve controlled by a solenoid. The solenoid is powered by a battery with a switch electrically coupled thereto. The plunger valve is interconnected to the carburetor to allow additional air entrainment. The solenoid is coupled to the valve for opening and closing the valve. The switch electrically couples the solenoid to the battery to activate the solenoid for movement of the valve. The switch disclosed herein includes a temperature sensor and an engine-running sensor. The switch is then closeable when the temperature sensor detects an engine temperature within a predetermined range as long as the engine is not already running.

Hot-start solenoid valve

Growing community of inventors

Rancho Santa Fe, CA, United States of America

Michael Aidan North