Nestec S.a.

Societe Des Produits Nestle S.a.

Givaudan S.a.

Michael Affolter

Clara Lucia Garcia-Rodenas

Eduardo Schiffrin

Annick Mercenier

Peter Erdmann

Sunil Kochhar

Peter Van Den Broek

Michel Monod

Isabelle Bureau-Franz

Irène Corthesy-Theulaz

Laurent Ameye

Sylvie Tournade

Carlos Antonio DeCastro

Marcel-Alexandre Juillerat

Johannes De Reu

Francoise Maynard

Alexandre Panchaud

Jacques-Edouard Germond

Martin Grigorov

Mario Labeta

Cristina Hering-Giovanola

Agnes Doumas

Christophe Fuerer

Françoise Maynard

Ulrich Zachariae

Laurent-Bernard Fay

A maternal composition wherein said maternal composition is specifically formulated for a woman who has given birth prematurely or who is at risk of giving birth prematurely.

Maternal supplement

The present invention relates to a preterm human milk fortifier composition, more specifically to a preterm milk fortifier composition providing one or more specific nutrient in amounts that are missing in human milk of women who gave birth to a preterm infant. In particular the present invention relates to a fortifier composition designed for infants as a supplement to preterm human breast milk at the time the infant leaves the hospital (discharge) and after. The invention furthermore relates to the use of said preterm human milk fortifier composition.

Human milk fortifier composition

A composition including protein hydrolysates derived from milk is obtained by the treatment of enzymes derived from microorganisms. A trypsin-like enzyme and a chemotrypsin-like enzyme are used. The composition is in particular intended for inducing tolerance in infants with the effect of modulating the potential occurrence of allergies later in life. The composition can also be used in sick adult patients. Preferably the composition is an infant formula, infant follow-up formula, growing-up milk or baby food or an enteral complete nutritional composition.

Milk-based protein hydrolysates and infant formulae and nutritional compositions made thereof

The present invention relates to novel strains ofthat can produce high amounts of hypotensive peptides, in particular IPP, VPP and LPP. It also relates to a fermented milk product containing a mixture of tripeptides IPP-VPP-LPP and a strain of. The invention further relates to the specific peptide mixture consisting of tripeptides IPP, VPP and LPP and the use of the fermented product or mixture of peptides in food products, food supplement or pharmaceutical compositions for reducing or preventing hypertension.

Lactobacillus helveticus strains for producing hypotensive peptides

The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the present invention pertains to a mutation in the creA gene as a tool to increase the amount of a wide spectrum of proteolytic enzymes in the presence of a carbon source.

Expression of proteolytic enzymes in koji mold in the presence of carbon sources

A novel, soluble protein similar to the known Toll-like receptor (TLR) family is disclosed. The present invention relates to these new soluble polypeptides, to nucleotide sequences encoding the polypeptides, to antibodies selectively binding to the polypeptide and to expression systems suitable for producing the polypeptide. The polypeptide is useful for modulating inflammatory reactions in mammals that include the actions of TLR.

Soluble toll-like receptor

This invention relates to a process for the production of a cultured savory base by hydrolyzing a protein-containing material using a combination of at least one enzyme with at least one thermotolerant lactic acid bacteria strain selected for its ability to provide a glutaminase activity. The invention also relates to an isolated strain of thermotolerant lactic acid bacteria strains selected for their ability to provide a glutaminase activity and their use for preparing a seasoning or flavor for culinary or petfood products.

Cultured protein hydrolysate

The invention has for object the new recombinant prolyl-dipeptidyl-peptidase enzyme (DPP IV) from,comprising the amino-acid sequence from amino acid 1 to amino acid 755 of SEQ ID NO:2 or functional derivatives thereof, and providing a high level of hydrolyzing specificity towards proteins and peptides starting with X-Pro- thus liberating dipeptides of X-Pro type, wherein X is any amino acid. The invention also provides a DNA molecule encoding the enzyme according to the invention, cells expressing the enzyme according to the invention by recombinant technology, an Aspergillus naturally providing a prolyl-dipeptidyl-peptidase activity which has integrated multiple copies of the Aspergillus native promoter which naturally directs the expression of the gene encoding the prolyl-dipeptidyl-peptidase activity, Aspergillus naturally providing a prolyl-dipeptidyl-peptidase activity which is manipulated genetically so that the dppIV gene is inactivated. The invention provides a method for producing the enzyme according to the invention, comprising cultivating the cells of the invention in a suitable growth medium under conditions that the cells express the enzyme, and optionally isolating the enzyme in the form of a concentrate. The invention provides the use of the enzyme or the cells of the invention to hydrolyze protein containing materials. The invention provides the use of an enzyme and/or a cell providing a prolyl-dipeptidyl-peptidase activity, in combination with at least an enzyme providing a prolidase to hydrolyze protein containing materials. In a last further aspect, the invention provides a food product comprising a protein hydrolyzate obtainable by fermentation with at least a microorganism providing a prolyl-dipeptidyl-peptidase activity higher than 50 mU per ml when grown in a minimal medium containing 1% (w/v) of wheat gluten.

Cloning of the prolyl-dipeptidyl-peptidase from Aspergillus oryzae

Enhanced expression of proteolytic enzymes in koji mold

Growing community of inventors

Savigny, Switzerland

Michael Affolter