Hoechst (uk) Limited

Hoechst Aktiengesellschaft

Michael A Yeomans

Graham Johnson

Barry C Ross

What are disclosed are compounds, useful as intermediates in the preparation of substituted penem compounds, of the formula ##STR1## wherein R is a removable esterifying group, R.sup.1 is lower alkyl or phenyl, R.sup.2 is hydrogen, lower alkyl, lower alkoxyalkyl, lower alkanoyloxyalkyl, or tri-lower alkylsilyloxyalkyl, and R.sub.a, R.sub.b, R.sub.c, R.sub.d, and R.sub.e are hydrogen, aliphatic cycloaliphatic hydrocarbon, free or esterified carboxyl, halo, or cyano, and any two of R.sub.a -R.sub.e, taken together, may form a cycloaliphatic ring.

3,3-Di(acylthio)-2(4-allylthioazetidin-2-on-1-yl)propenoic acid ester

What are disclosed are compounds, useful as intermediates in the preparation of substituted penem compounds, of the formula ##STR1## wherein R is a removable esterifying group, R.sup.2 is hydrogen, lower alkyl, lower alkoxyalkyl, lower alkanoyloxyalkyl, or tri-lower alkylsilyloxyalkyl, and R.sub.a, R.sub.b, R.sub.c, R.sub.d, and R.sub.e are hydrogen, aliphatic cycloaliphatic hydrocarbon, free or esterified carboxyl, halo, or cyano, and any two of R.sub.a -R.sub.e, taken together, may form a cycloaliphatic ring.

2(4-Allylthioazetidin-2-on-1-yl)acetic acid ester compounds

What are disclosed are compounds, useful as intermediates in the preparation of substituted penem compounds, of the formula ##STR1## methods for making such compounds from intermediates of the formula ##STR2## by reaction of the latter with a nucleophilic compound, methods for making such intermediates from compounds of the formula ##STR3## by reaction of the last-mentioned compounds with a tervalent phosphorus compound, and methods for making said last-mentioned compounds by cyclizing compounds of the formula ##STR4## with a tervalent phosphorus compound.

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Liederbach, Germany

Michael A Yeomans