Monsanto Company

Feder, Joseph

Sanzo, Michael A.

Hardy, Medora, M.

Michael A Sanzo

Joseph Feder

Arthur J Wittwer

Medora M Hardy

Jayne C Marasa

Medora Hardy

Joseph (nmn) Feder

The present invention is directed to hydroponic systems that can be used in an environment with large daily fluctuations in temperature and to the use of those systems for growing plants.

Hydroponic system for use in a desert-like environment

A novel and unique plasminogen activator inhibitor fragment is obtained from human umbilical vein endothelial cells which has the following characteristics:

Tissue plasminogen activator inhibitor and method of purification

Novel peptide fragments of tissue plasminogen activator are described which have activity for inhibiting (a) the binding of tPA to human endothelial cells, and (b) the inactivation of tPA by plasminogen activator inhibitor-1 (PAI-1). Six peptides or peptide amides with these activities have the sequences, numbered according to the native protein:

Peptide fragments of tissue plasminogen activator

A method is disclosed for increasing the yield of t-PA in culture of mammalian cells comprising introducing antibodies to the t-PA of said cells into the cell culture nutrient medium, allowing the cells to grow, and then recovering t-PA from the t-PA-antibody complex thus found in the conditioned medium by exchanging antibody in the complex for t-PA antibody immobilized on an inert support.

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St. Louis, MO, United States of America

Michael A Sanzo