Merck + Co., Inc.

The Salk Institute for Biological Studies

Mitobridge, Inc.

Novartis Ag

Millennium Pharmaceuticals Limited

Epizyme, Inc.

Synaptic Pharmaceutical Corporation

Eyegate Pharmaceuticals, Inc.

Ore Pharmaceuticals Inc.

Other

Abbott Laboratories Corporation

Bantam Pharmaceutical, LLC

Novartis Pharma Gmbh

Astellas Engineered Small Molecules Us, Incorporated

Michael A Patane

Mark G Bock

Mark E Duggan

John Howard Hutchinson

Robert S Meissner

Ronald Mark Evans

Arthur F Kluge

Ben C Askew

Michael Downes

Bharat Lagu

Masanori Miura

Christopher Blackburn

Taisuke Takahashi

Ramesh Senaiar

Sunil Kumar Panigrahi

Susanta Samajdar

Wasyl Halczenko

Jiabing Wang

Michael E Solomon

Thomas G Steele

George D Hartman

Richard Chesworth

Harold G Selnick

Kevin Wayne Kuntz

Roger M Freidinger

Dhanapalan Nagarathnam

Paul J Coleman

Edward James Olhava

Jiping Fu

Christopher F Claiborne

James J Perkins

Wai C Wong

Natalie Alysia Dales

Tricia J Vos

Trixi Brandl

David Thomas Parker

Aregahegn Yifru

Prakash Raman

Courtney A Cullis

Oliver Simic

Pascal Rigollier

Mohindra Seepersaud

Gary Paul Cook

Rui Zheng

Perry Calias

Branko Radetich

Francois Lenoir

Mike Jaffe

Randall C Newton

Rose Ann Ponticello

Charles Gluchowski

Matthew J LaMarche

Martin P Maguire

Michael J Breslin

Gabriel S Weatherhead

Cecilia A Hunt

James A Brown

Omar Stradella

Mihaela D Danca

Andrew J Souers

Philip R Kym

William C Lumma, Jr

Anil Vasudevan

Susan Laurene Acton

Ulf H Dolling

Rajesh R Iyengar

Su-Jen Lai

Timothy D Ocain

Bing Guan

Mathew M Mulhern

Thomas H Marsilje, Iii

Linda S Payne

Dariusz Wodka

Jacob M Hoffman

Daniel Richard Sidler

Alexandra E Gould

Scott Trzaska

Robert M DiPardo

Matthew Stirling

Garry R Smith

Shou Wu Miao

Ju Gao

Lewis Whitehead

Mingshi Dai

John K Lynch

Simon Bushell

Jennifer C Freeman

Jennie B Nerenberg

Alain Stricker-Krongrad

Mary Katherin Verzal

Aiwen Li

Roger M Friedinger

Vivek J Kadambi

Jennifer L Che

Marg G Bock

Essa Hsinyi Hu

Effie Tozzo

Matthew J Lamarche

Provided herein are compounds and compositions useful in increasing PPAR&#x3b4; activity. The compounds and compositions provided herein are useful for the treatment of PPAR&#x3b4; related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof

Provided herein are compounds I, II or III and compositions useful in increasing PPAR8 activity. The compounds and compositions provided herein are useful for the treatment of PPAR8 related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases). 

Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.

Ocular iontophoretic delivery of dexamethasone and formulations thereof

Provided herein are compounds of formula (I) useful for the treatment of PPAR-delta related diseases (e.g. mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases). 

Delivery of corticosteroids through iontophoresis

Disclosed herein are compounds, compositions, formulations, kits and methods of treatment useful for treating or preventing one or more hyperproliferative disorders, e.g., cancer or a neurological disease or disorder.

Compositions and methods for treating or preventing diseases or disorders associated with misregulated EIF4E

Disclosed are compounds, pharmaceutical compositions containing the compounds, uses of the compounds and compositions as modulators of histone methyltransferases, and methods for treating diseases influenced by modulation of histone methyltransferase activity.

7-deazapurine modulators of histone methyltransferase, and methods of use thereof

Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.

Modulators of histone methyltransferase, and methods of use thereof

The present invention provides a method of treating a HCV infection in a subject in need thereof by administering a compound of Formula I: or pharmaceutically acceptable salts thereof or stereoisomers thereof.

Organic compounds and their uses

The present application describes organic compounds of the Formula I that are useful for the treatment, prevention and/or amelioration of human diseases. 

The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Lactam compounds useful as protein kinase inhibitors

Growing community of inventors

Harleysville, PA, United States of America

Michael A Patane