Nereus Pharmaceuticals, Inc.

University Of California

Other

Dana-Farber-Cancer Institute Inc.

Ixsys, Incorporated

Beyondspring Pharmaceuticals, Inc.

Celgene International II Sarl

Triphase Research and Development I Corp.

Nereus Pharmacuticals, Inc.

Michael A Palladino

Yoshio Hayashi

Emmanuel A Theodorakis

George Kenneth Lloyd

Jennifer Grodberg

Kenneth Carl Anderson

Dharminder Chauhan

William D Huse

Judith A Varner

Venkat Rami Reddy Macherla

Ta-Hsiang Chao

Saskia Theodora Cornelia Neuteboom

Bruce Andrew Lee

Kin S Lam

Barbara Christine Potts

Benjamin Nicholson

Venkata Rami Reddy Macherla

Ginger Tsueng

Irene M Ghobrial

Aldo M Roccaro

Young Ger Suh

Young-Ger Suh

Saskia Theodora Neuteboom

Venkata Rami Macherla

Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma.

Compositions and methods for treating neoplastic diseases

Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Analogs of dehydrophenylahistins and their therapeutic use

Disclosed are methods of treating Waldenstrom's Macroglobulinemia comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula I.

Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia

Disclosed are methods of treating cancer, inflammatory conditions, and/or infectious disease in an animal comprising: administering to the animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent.

Methods of using [3.2.0] heterocyclic compounds and analogs thereof

Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural products and novel, structurally-related chemical compounds. More particularly, disclosed are new analogs of and processes for the preparation of compounds and pharmaceutical compositions thereof useful in the treatment of, for example, inflammation, cancer, multiple myeloma, cachexia, cardiovascular disease, anti-infectious, diabetes, otitis media, sinusitis and transplant rejection.

Interleukin-1 and tumor necrosis factor-&#x3b1; modulators; syntheses of such modulators and methods of using such modulators

Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R, R', R&#x2032;, R, R, R, R, and R, Xand X, Y, Z, Z, Z, Z, and Zmay each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof

Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R, R', R&#x2033;, R, R, R, R, and R, Xand X, Y, Z, Z, Z, Z, and Zmay each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

Interleukin-1 and tumor necrosis factor-&#x3b1;modulators; syntheses of such modulators and methods of using such modulators

Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R, R', R&#x2033;, R, R, R, R, and R, Xand X, Y, Z, Z, Z, Z, and Zmay each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent.

Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions.

Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs

Growing community of inventors

Olivenhain, CA, United States of America

Michael A Palladino