Wisconsin Alumni Research Foundation

Michael A Newton

David Charles Schwartz

Paul G Ahlquist

Paul F Lambert

Dohun Pyeon

Konstantinos Dimitrios Potamousis

Rodney Runnheim

Christopher P Churas

Daniel K Forrest

Shiguo Zhou

Steven J Goldstein

Subhrangshu Nandi

Konstantinos D Potamousis

Rodney A Runnheim

Systems and methods for identifying sequence information from measurements made on single nucleic acid molecules are disclosed. The systems and methods can include binding portions of nucleic acid molecules with marker molecules, such as fluorescent molecules and/or intercalating molecules. The marker molecules provide a detectable signal that includes information about the underlying genomic information of the location on the nucleic acid molecule where a given marker molecule is bound. A profile of the detectable signal along a position of the nucleic acid is acquired for multiple different nucleic acid molecules. The PRIMR algorithm processes the data to provide a consensus profile from which a consensus underlying genomic information can be determined.

Systems and methods for identifying sequence information from single nucleic acid molecule measurements

Cervical cancer cells and HPVhead and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.

Biomarkers for human papilloma virus-associated cancers

Methods are provided for ascertaining the sequence of a genomic DNA sample by nicking the DNA sample with a restriction nicking enzyme, followed by nick translation with labeled nucleotides, such that the labeled nucleotides can be quantified and compared to a known, reference genome.

Methods of whole genome analysis

Biomarkers for human papilloma virus-associated cancer

Growing community of inventors

Madison, WI, United States of America

Michael A Newton