University of California

Other

Massachusetts Institute of Technology

Michael A Marletta

Stephen P L Cary

Jonathan A Winger

Elizabeth M Boon

William T Beeson, Iv

Emily Weinert

James Harrison Doudna Cate

Stephen Jacob Goldfless

Brian J Belmont

Jacquin Clarence Niles

James H Dounda Cate

Stephen Pl Cary

Stephen P Cary

Stephen PL Cary

H&#x2014;NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas Odelivery. The engineered H&#x2014;NOX proteins comprise mutations that impart altered Oor NO ligand-binding relative to the corresponding wild-type H&#x2014;NOX domain, and are operative as physiologically compatible mammalian blood Ogas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H&#x2014;NOX proteins for the treatment of any condition for which delivery of Ois beneficial.

Compositions and methods for the delivery of oxygen

H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or Oligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial.

Compositions and methods for the delivery of nitric oxide

H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas Odelivery. The engineered H-NOX proteins comprise mutations that impart altered Oor NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood Ogas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of Ois beneficial.

In vitro SELEX has been used to discover high affinity RNA aptamers interacting with the tetracycline repressor protein in a tetracycline-dependent manner. Using in silico RNA folding predictions to guide the design of both aptamer truncations and mutants, minimized tetracycline repressor protein high affinity binding aptamers have been defined. Using one such aptamer, inducible post-transcriptional regulation in vivo has been demonstrated that is predicated on a direct interaction between a tetracycline repressor protein and a RNA aptamer element. These aptamer components can be integrated in any organism to inducibly regulate RNA translation of a gene of interest.

Post-transcriptional regulation of RNA-related processes using encoded protein-binding RNA aptamers

The present disclosure relates to hydrolysis of hexose-&#x3b4;-lactones by use of anextracellular aldonolactonase. In particular the present disclosure relates to compositions including aextracellular aldonolactonase and methods of use thereof.

Extracellular aldonolactonase

An electric light balloon containing a balloon, a housing for insertion into the balloon, access for inflation, illumination device, power supply, and a way for activating the system wherein the housing contains an orifice at its top end directly in line with the longitudinal axis of the balloon to allow direct light to enter the balloon from the bulb.

Electric light balloon

A device placed upon a guitar in order to change a sound produced by the guitar into a sound of a zither or balilaika; the device consisting of a bridge mounted upon the guitar top panel or table and which straddles the six strings, and six hammers depending downward freely from the bridge to a position alongside each string so that the vibrating string will bounce the hammer resulting in a tinkling sound.

Growing community of inventors

Berkeley, CA, United States of America

Michael A Marletta