Other

University of Tennessee Research Foundation

Michael A Kehoe

Edwin H Beachey

Thomas P Poirier

Michael Pinkney

This application teaches a cytolytic derivative of the thiol-activated protein streptolysin O. The derivatization comprises the deletion of the amino acid cysteine from the amino acid sequence of naturally occurring streptolysin O; end optionally other alterations in said naturally occurring amino acid sequence by amino acid substitution, deletion, inversion, insertion or addition.

Streptolysin O antigen derivatives, their production and uses

A non-toxic and non-cytolytic derivative of streptolysin O which retains at least one (preferably immunodominant) epitope is produced, and can be used especially in diagnostic tests for detecting of the presence of antibodies to Streptococcus pyogenes in a sample.

Streptolysin O antigen derivatives, its production and uses

Non-virulent aro-Salmonella typhimurium bacterium is disclosed into which has been cloned a heterologous nucleotide sequence encoding for the expression of Streptococcal M protein antigen from S. pyogenes seratype 5, which is effective to elicit opsonic antibodies against Streptococcal infections. The bacterium is useful for vaccination against Streptococcus pyogenes bacteria.

Therapeutic compositions against streptococcal infections, transformed

Non-virulent bacteria are disclosed into which have been cloned heterologous nucleotide sequences encoded for the expression of Streptococcal M protein antigens, which are effective to elicit opsonic antibodies against Streptococcal infections. These bacteria are useful for vaccination against Streptococcus pyogenes bacteria.

Growing community of inventors

Durham, United Kingdom

Michael A Kehoe