Commonwealth Scientific and Industrial Research Organisation

Vectogen Pty Ltd.

Michael A Johnson

Richard J McCoy

Michael G Sheppard

Jeffrey Michael Hammond

John William Lowenthal

Jennifer Joy York

Jeffrey Hammond

Terri E O'Neil

Christopher T Prideaux

Methods are provide to allow for the preparation of adenoviral vectors with altered tropism. Compositions comprising such vectors and methods of use thereof also are provided.

Methods and compositions for increasing tissue tropism of recombinant adenoviral vectors

This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinant of Hog Cholera Virus or Pseudorabies virus. The further invention relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting pigs from disease.

Recombinant porcine adenovirus vector

The present invention provides compositions comprising recombinant avian IFN-&ggr; polypeptides and methods using said recombinant avian IFN-&ggr; polypeptides and compositions to enhance the immune responses of birds, and to enhance growth and/or prevent weight loss in birds. The present invention is particularly useful in the prophylactic and therapeutic treatment of birds against coccidiosis and the causative agent thereof.

Uses of avian interferon gamma (IFN-&ggr;)

This invention relates to a recombinant vector comprising a recombinant avian adenovirus incorporating, and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinate of infectious bursal disease virus. The invention further relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting poultry from disease.

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Thornbury, Australia

Michael A Johnson