Westinghouse Electric Company LLC

The Medical College of Wisconsin, Inc.

Michael A James

Jorge V Carvajal

Robert W Flammang

Nicola G Arlia

Michael D Heibel

Melissa M Walter

David M Sumego

John G Seidel

Ming You

Haris G Vikis

Provided herein are therapeutic agents having specificity for human CLPTM1L/CRR9 polypeptide, including therapeutic agents comprising one or more CLPTM1L-targeting agents, compositions comprising such therapeutic agents, and methods of using such compositions for treating or preventing a cancer, pre-cancerous lesion, or other disease condition associated with CLPTM1L/CRR9 protein dysfunction (e.g., pathogenic production, modification, or function). In particular, provided herein are fully human monoclonal antibodies against human CLPTM1L/CRR9 protein and methods of using such antibodies for treating or preventing a cancer, pre-cancerous lesion, or other disease condition associated with CLPTM1L/CRR9 protein dysfunction (e.g., pathogenic production, modification, or function).

Targeting CLPTM1L for treatment and prevention of cancer

A method and a system for performing real-time, continuous, measurements of the boron concentration in the water entering a nuclear reactor coolant system. The invention utilizes knowledge of the impact that boron contained in liquid water has on the attenuation of acoustic or ultrasonic waves. This information, coupled with radiation damage resistant and high temperature operability capable transmitter and receiver equipment, provides the means to place the measurement system sensors and signal processing electronics on the reactor coolant system charging flow piping or the hot leg or cold leg of the reactor coolant loop. This will allow the reactor operator to directly monitor both the reactor coolant system boron concentration value and detect changes in the reactor coolant system boron concentration relative to a reference value as they occur.

Real-time reactor coolant system boron concentration monitor utilizing an ultrasonic spectroscpopy system

A system that measures the temperature distribution of the reactor coolant flowing through the hot leg or cold leg pipes by measuring the speed of sound time delay. This concept uses radiation hardened and temperature tolerant ultrasonic signal drivers based on vacuum micro-electronic technology. The system employs ultrasonic signals propagated through water, and relies on the characteristic that the speed of sound changes as the density and temperature of the water changes. Thus, a measured difference in the speed of sound in water may be directly correlated to a temperature change of the water.

Reactor coolant system piping temperature distribution measurement system

Provided herein are therapeutic agents having specificity for human CLPTM1L polypeptide, including therapeutic agents comprising one or more CLPTM1L-targeting agents, compositions comprising such therapeutic agents, and methods of using such compositions for treating or preventing a cancer, pre-cancerous lesion, or other disease condition associated with CLPTM1L protein dysfunction (e.g., pathogenic production, modification, or function).

Apparatus for amplifying low level signals within a nuclear plant's containment building, derived from the ex-core nuclear instrumentation system. The system employs vacuum micro-electronic devices in place of conventional pre-amplifier assemblies to position the pre-amplifier assemblies closer to and within the vicinity of the ex-core detector outputs.

In-containment ex-core detector system

Provided herein are therapeutic agents having specificity for human CLPTM1 L polypeptide, including therapeutic agents comprising one or more CLPTM1 L-targeting agents, compositions comprising such therapeutic agents, and methods of using such compositions for treating or preventing a cancer, pre-cancerous lesion, or other disease condition associated with CLPTM1 L protein dysfunction (e.g., pathogenic production, modification, or function).

A pulsed sonar-based wireless rod position indication system that utilizes nuclear radiation and high temperature tolerant hardware. The pulsed sonar-based rod position indication system can precisely locate the rod position by measuring the time of flight of a transmitted signal and by using the phase and amplitude information of the same transmitted signal. Primary and secondary antenna probes located in the interior of the control rod drive rod travel housing and full hardware redundancy provide for improved accuracy. The time of flight, phase and amplitude raw signals are inputted to a wireless data transmitter capable of sending the raw signals to a receiver antenna located elsewhere inside a containment for further processing.

Nuclear control rod position indication system

Provided herein are compositions for reducing CLPTM1L expression in a cell as well as methods for using such compositions to treat or prevent cancer in a subject. In particular, compositions comprising RNAi-inducing constructs targeted to CLPTM1L and methods of administering such compositions to a subject to treat or prevent a disease or condition associated with CLPTM1L over-expression (e.g., lung cancer) are provided herein.

Targeting CLPTM1L by RNA interference for treatment and prevention of cancer

An in-core neutron monitor that employs vacuum microelectronic devices to configure an in-core instrument thimble assembly that monitors and wirelessly transmits a number of reactor parameters directly from the core of a nuclear reactor without the use of external cabling. The in-core instrument thimble assembly is substantially wholly contained within an instrument guide tube within a nuclear fuel assembly.

Wireless in-core neutron monitor

An improved apparatus for determining the position of a drive rod within the interior of a drive rod housing includes a transmission antenna at one location on the housing and a receiving antenna at another location on the housing. An electromagnetic excitation signal sent to the transmission antenna is detected, at least in part, by the receiving antenna, and the received signal is processed with a vector network analyzer routine to model the drive rod housing as a wave guide having a filter response. A group delay is detected and is compared with a calibration data set which provides a current position of the drive rod that corresponds with the group delay.

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Harmony, PA, United States of America

Michael A James