Children's Hospital Medical Center

University of Cincinnati

Michael A Helmrath

Ardythe L Morrow

James Macormack Wells

Michael Workman

Chia-Ying James Lin

Jorge Orlando Munera

Stacey Gruber

John Van Aalst

Ethan Mezoff

Carey Lane Watson

Alessandro De Alarcon

Maxime Mickael Mahe

Disclosed are methods for making a vascularized hollow organ derived from human intestinal organoid (HIOs). The HIOs may be obtained from human embryonic stem cells (ESC's) and/or induced pluripotent stem cells (iPSCs), such that the HIO forms mature intestinal tissue. Also disclosed are methods for making a human intestinal tissue containing a functional enteric nervous system (ENS).

Method of making in vivo human small intestine organoids from pluripotent stem cells

Various aspects of the disclosure relate to a tracheal implant comprising (a) a trachea processed to comprise one or more incisions providing a helical configuration to the processed trachea; and (b) a subject-specific synthetic support.

3D printed spiral for hybrid tracheal replacement scaffolds

Provided herein are compositions and methods related to use of oligosaccharides, such as 2'-fucosyllactose, for increasing weight gain in a subject. In some aspects the compositions and methods are for use in infants, such as premature infants or infants having intestinal failure.

Use of oligosaccharide compositions to enhance weight gain

Growing community of inventors

Cincinnati, OH, United States of America

Michael A Helmrath