Medtronic, Inc.

Nellix, Inc.

Bacchus Vascular Inc.

Devices for Vascular Intervention, Inc.

Medtronic Ave, Inc.

Endologix, Inc.

Covidien LP

Other

Tyco Healthcare Group LP

Cardiovascular Concepts, Inc.

Medtronics, Inc.

Innerdyne, Inc.

Flosstime Inc.

Medtronic Vascular, Inc.

Interventional Thermodynamics, Inc.

Michael A Evans

Gwendolyn A Watanabe

Jay Alan Lenker

Steven W Kim

Steven Lawrence Herbowy

Denise M Demarais

Amy Catherine Lee

Kirsten Freislinger

Stephen Arie Leeflang

Christian Scott Eversull

Brian J Cox

Allan R Will

Steven Weinberg

Will R Dubrul

Alexander K Khairkhahan

Dino De Cicco

K T Venkateswara Rao

Timothy J Ryan

Brian A Glynn

Kelvin Ning

John C Tanner, Iii

Tyler Jon Strang

Thomas J Fogarty

Richard L Mueller, Jr

Gil Laroya

Matthew R Hellewell

Anant Kumar

Richard O Murphy

George D Hermann

Emily A Stein

Edward V Kinney

Christopher Loew

Darin Charles Gittings

William Richard Dubrul

Thomas H Howell

Colin J Nichols

Kondapavulur T Venkateswara-Rao

James T McKinley

Sherwin Llamido

Christopher K Zarins

Bhupendra Shah

Duc Duong

Sylvie Lombardi

Gregorio Faria

Thomas A Howell

Bernard H Andreas

Denise Marie Zarins

Charles S Taylor

John B Simpson

Brian Eugene Farley

Robert S Behl

Christopher Zarins

Thomas Grimm

Craig J Coombs

Raj P Ganpath

Dino DeCicco

Deborah Tolomeo

Raymond S Figueroa, Jr

Gwendolyn A Wantanabe

Craig Rosenberg

Sascha K Zarins

Glen R Davis

Denise Demarias

Kt Venkateswara Rao

Laura Kemp

Hen Lao

Robert Wotring

Jody Maria Cimbalo

Christian S Eversull

Denise DeMarais

James Mckinley

John C Iii Tanner

A system for treating an aneurysm comprises an elongate flexible shaft and an expandable member. An expandable scaffold is disposed over the expandable member and may be expanded from a collapsed configuration to an expanded configuration. A double-walled filling structure is disposed over the scaffold and has an outer wall and an inner wall. The filling structure is adapted to be filled with a hardenable fluid filing medium so that the outer wall conforms to an inside surface of the aneurysm and the inner wall forms a substantially tubular lumen to provide a path for blood flow. In the expanded configuration the scaffold engages the inner wall of the filling structure. A tether is releasably coupled with the filling structure and the flexible shaft thereby constraining axial movement of the structures relative to each other.

Stent graft delivery system

Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.

Graft systems having filling structures supported by scaffolds and methods for their use

Aneurysms are treated by placing a scaffold across an aneurysmal sac to provide a blood flow lumen therethrough. An aneurysmal space surrounding the scaffold is filled with one or more expandable structures which are simultaneously or sequentially expanded to fill the aneurysmal space and reduce the risk of endoluminal leaks and scaffold migration. The expandable structures are typically inflatable and delivered by delivery catheter, optionally with an inflation tube or structure attached to the expandable structure.

Methods and systems for aneurysm treatment using filling structures

Disclosed herein are nutraceutical compositions comprising or consisting essentially of one or more types of polyphenols (e.g., a green tea polyphenol) and one or more types of reactive oxygen species, and methods for their use to treat gastrointestinal conditions, inflammatory conditions, and immune conditions.

Polyphenol-reactive oxygen species compositions and methods

Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium. An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device while and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint. The medium is hardened while the lumen remains supported by the balloon. The balloon is then removed after the medium hardens.

Systems and methods for endovascular aneurysm treatment

Floss dispensers are described. In one embodiment, a floss dispenser includes a housing and a feeder coupled to the housing. The feeder may be configured to feed a length of floss from a spool of floss. The floss dispenser also includes a spout formed in the housing. The spout may have a cutter entry and a cutter exit. The floss dispenser also includes a cutter coupled to the housing. The cutter may be coupled to the housing between the cutter entry and the cutter exit. The spout may be configured to guide the length of floss to the cutter.

Floss dispensers

A molecular net formed as a branched pseudorandom copolymer including two broad classes of subunits: capture agents and linking agents. The subunits self-assemble to form a structure capable of binding to predetermined targets. The binding can then be detected.

Molecular nets comprising capture agents and linking agents

Floss dispenser

Methods and systems for treating aneurysms using filling structures filled with a curable medium are described herein. Such methods can include positioning a double-walled filling structure across the aneurysm and filling with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device during and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint.

System and methods for endovascular aneurysm treatment

Various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue.

Methods for renal denervation

Growing community of inventors

Palo Alto, CA, United States of America

Michael A Evans