University of Utah Research Foundation

Therma-wave, Inc.

Michael A Ellison

Baldomero M Olivera

J Michael McIntosh

David S Wang

James Lee Hendrix

Joel Ng

Michelle Vincler

J Michael Mcintosh

The present invention relates to the use of compounds that block the &#x3b1;9&#x3b1;10 subtype of the nicotinic acetylcholine receptor (nAChR) for treating pain, such as neuropathic pain and inflammatory pain, and inflammatory disorders, such as arthritis. The present invention also relates to screening compounds to identify analgesic agents that block the &#x3b1;9&#x3b1;10 subtype of the nAChR.

Methods for treating pain and screening analgesic compounds

The present invention relates conotoxin peptides that are analogs of the &#x3b1;-conotoxin peptide RgIA. These conotoxin peptides block the &#x3b1;9&#x3b1;10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain, such as neuropathic pain and inflammatory pain, inflammatory disorders, such as rheumatic diseases, and in the treatment of breast cancer.

Conotoxin peptides

A combiner for optical beams includes a substrate overlaid by a multi-layer dielectric film stack. The substrate is a clear material and the dielectric film stack is a series of alternating layer of high and low refractive index. This gives the combiner relatively high reflectivity across UV wavelengths and relatively high transmissivity in the visible and longer wavelengths and allows visible light to pass through the combiner while UV light is reflected. At the same time dielectric film stack has minimal absorption and scatter. This means that the intensity of visible light maintains at least 90% of its intensity as it passes through combiner and UV light retains at least 90% of its intensity as it is reflected by combiner.

Beam splitter/combiner for optical metrology tool

Beam splitter/combiner for optical meterology tool

Growing community of inventors

Boulder, CO, United States of America

Michael A Ellison