Intarcia Therapeutics, Inc.

Horizon Orphan LLC

Durect Corporation

Michael A Desjardin

Pauline C Zamora

Guohua Chen

Catherine Manya Rohloff

Andrew S Luk

Rupal A Ayer

Paul R Houston

Stan Lam

Pedro E De La Serna

Mark Johnson

Scott D Lautenbach

Thomas R Alessi

Gunjan H Junnarkar

John P Carr

Scott C Lautenbach

The present invention is related to methods for lowering peroxide levels in sucrose acetate isobutyrate formulations and to composition used in and formed by such methods.

Peroxide removal from drug delivery vehicle

Methods of storing and methods of stabilizing pharmaceutical compositions comprising cysteamine, or a pharmaceutically acceptable salt thereof, are provided. Methods of distributing pharmaceutical compositions comprising cysteamine, or a pharmaceutically acceptable salt thereof, and methods of treating cystinosis also are provided.

Methods for storing cysteamine formulations and related methods of treatment

Methods for storing Cysteamine formulations and related methods of treatment

An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.

Two-piece, internal-channel osmotic delivery system flow modulator

A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

Solvent/polymer solutions as suspension vehicles

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Aptos, CA, United States of America

Michael A Desjardin