Harvard College

The Broad Institute, Inc.

Dana-farber-cancer Institute Inc.

Intellia Therapeutics, Inc.

Micah Maetani

Stuart L Schreiber

Benito Munoz

Eamon Comer

Nobutaka Kato

Jeremy Duvall

Christina Scherer

Jennifer A Beaudoin

Bertrand Braibant

Cigall Kadoch

Enrique Garcia-Rivera

Sebastian T Le Quement

Stephen S Scully

Ramsey Majzoub

The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.

Modified amine lipids

The present invention includes compound and methods that are useful in treating certain cancers, such as synovial sarcomas.

Compounds and methods for treating synovial sarcomas

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria. 

Compounds for the treatment of malaria

Growing community of inventors

Cambridge, MA, United States of America

Micah Maetani