Achaogen, Inc.

Syngenta Corporation

Syngenta Crop Protection, Inc.

Cipla Usa, Inc.

Micah James Gliedt

Martin Sheringham Linsell

James Bradley Aggen

Paola Dozzo

Darin James Hildebrandt

Adam Aaron Goldblum

Timothy Robert Kane

Heinz Ernst Moser

Shy-Fuh Lee

Frederick Cohen

Qing Lu

Glenn McEnroe

Ramesh Annasaheb Kasar

Brian D Patterson

Camilla Corsi

Ulrich Johannes Haas

Stephen Hanessian

Sebastian Volker Wendeborn

Carla Bobbio

Jilali Kessabi

Peter Schneiter

Valeria Grasso

Alexandre Giguère

Justyna Grzyb

Juan Pablo Maianti

Darin Hildebrandt

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q, Q, Q, Rand Rare as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Antibacterial aminoglycoside analogs

Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Antibacterial agents

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Qand Qare as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q, Q, Q, R, R, R, Zand Zare as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

The present invention relates to isoxazole compounds of formula (I) having fungicidal activity, to agricultural compositions comprising them, and to the use of said compounds and compositions in agriculture for the control of microbial pests, particularly fungal pests, on plants. 

Isoxazole derivatives for use as fungicides

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q, Q, Z, Z, Z, Z, R, Rand Rare as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q, Q, R, Rand Rare as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

The present invention provides compounds of formula I: along with methods of making the same, compositions thereof, and methods of use thereof, particularly methods of use as fungicides.

Substituted isoxazoles as fungicides

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Sunnyvale, CA, United States of America

Micah James Gliedt