The Medical College of Wisconsin, Inc.

Aix-marseille Université

Université De Provence

Other

Centre National De La Recherche Scientifique

Iowa State University Research Foundation Inc

Mcw Research Foundation, Inc.

Université´ D'aix-marseille

Micael J Hardy

Balaraman Kalyanaraman

Olivier Ouari

Marcos Lopez

Jacek Michal Zielonka

Paul Tordo

Ming You

Ming Yang Zhao

Gang Cheng

Kathleen M Schmainda

Joy Joseph

Jean-Pierre Bernard Finet

Douglas Edward Prah

Oliver Ouari

Neil Hogg

Balaraman Kalyanaramn

Florence Nathalie Laurence Chalier

The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.

Mito-honokiol compounds and methods of synthesis and use thereof

The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.

Mito-lonidamine, compositions and methods of use

The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.

Modified mito-metformin compounds and methods of synthesis and use thereof

The present invention provides mito-honokiol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol compounds in the treatment of cancer.

Tc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging.Tc-Mito-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared toTc-MIBI.Tc-Mito-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.

99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors

A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.

In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging

Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of interest for directly detecting free radicals, especially free radicals in biological samples.

Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof

The present invention involves new nitrons carrying a positive charge, useful in trapping of free radicals and especially the superoxide radical, of general formula: 

Nitrons carrying a positive charge and usable in trapping free radicals, especially the superoxide radical

Growing community of inventors

Nîmes, France

Micael J Hardy