Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd.

Cspc Zhongqi Pharmaceutical Technology (shijiazhuang) Co., Ltd.

Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory

Cspc Zhongqi Pharmaceutical Technology Co., Ltd.

Miaorong Luo

Jian Li

Shuhui Chen

Zhifei Fu

Juan Yu

Fei Hong

Tingting Yin

Jinming Huang

Zhiliang Chen

Jinxia Lin

Yichao Zhuang

Wei Wang

Jie Li

Jikui Sun

Longhui Gao

Zaifang Ren

Jinxiang Zeng

Shicong Wang

Zhiyi Luo

Limei Yang

Zhibo Luo

Jiansong Wang

Yingxia Bao

Zhoufan Xie

Dongjie Hu

Yalei Cai

Wu Zhu

Yang Zhang

Disclosed are the solid form, crystalline form, crystal form A of a compound of formula (I), and a preparation method therefor, crystal form B and a preparation method therefor. Also disclosed are use of the solid form, crystalline form, crystal form A, and crystal form B in the preparation of drugs for the treatment of diseases related to FGFR.

FGFR inhibitor compound in solid form and preparation method therefor

Disclosed are a series of compounds with a nitrogen-containing spiro structure and an application thereof in the preparation of an RET kinase inhibitor. Specifically, disclosed is a compound as shown in formula (II) or a pharmaceutically acceptable salt thereof.

Nitrogen-containing spiro derivative as RET inhibitor

A crystal form of a pyrazin-2(1H)-one compound and a preparation method therefor. The present invention specifically related to a compound of formula (II) and a preparation method for a crystal form of the compound. 

Crystal forms C and E of pyrazin-2(1H)-one compound and preparation method therefor

Provided are crystalline forms of pyrazine-2(1H)-ketone compound and a preparation method thereof; specifically disclosed are a method for preparing the compound of formula (II) and crystalline forms thereof. 

Crystalline form and B crystalline form of pyrazine-2(1H)-ketone compound and preparation method thereof

The present invention disclosed a crystal form of pyrazine-2(1H)-ketone compound and a preparation method therefor. Specifically disclosed is a method for preparing a compound of formula (II) and a crystal form thereof. 

Crystal form D of pyrazine-2(1H)-ketone compound and preparation method therefor

Provided are preparation methods for the chemical compound represented by formula (I) and an intermediate thereof. 

Pyrazine-2(1H)-ketone compound preparation method

Disclosed are a compound as shown in formula (I), and an isomer thereof or a pharmaceutically acceptable salt thereof, and involved is the use thereof in the preparation of drugs for treating FGFR-associated diseases. 

Pyrazine-2(1H)-ketone compound acting as FGFR inhibitor

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Shanghai, China

Miaorong Luo