Korea Research Institute of Bioscience and Biotechnology

Y-biologics Inc.

Mi Ra Park

Young Woo Park

Seok Ho Yoo

Myeoung Hee Jang

Hye Nan Kim

Ki Won Jo

Kyu Won Cho

Seon Ha Yun

Chan Woong Park

Disclosed are a human antibody comprising a human complementarity-determining region (CDR), which binds specifically to c-Met, and a framework region (FR), a polynucleotide encoding the human antibody, an expression vector comprising the polynucleotide, a transformant transformed with the expression vector, a method of producing the human antibody B7 by culturing the transformant, a wound healing composition comprising the human antibody as an active ingredient, a cell regeneration composition comprising the antibody as an active ingredient, and a drug conjugate comprising a drug linked to the human antibody. The c-Met-specific human antibody can function as an HGF mimic that can be used as a wound healing composition. The antibody can be widely used to determine the treatment and prognosis of various diseases, including neuronal infarction, progressive nephropathy, liver cirrhosis, lung fibrosis, kidney injury, liver injury, lung injury, and ulcerative wounds, which are treated by activation of HGF or c-Met.

Anti-c-Met antibody having HGF activity and use thereof

Growing community of inventors

Daejeon, South Korea

Mi Ra Park