St. Jude Children's Research Hospital

Coa Therapeutics, Inc.

Mi Kyung Yun

Richard Edward Lee

Charles O Rock

Suzanne Jackowski

Chitra Subramanian

Robert J Zamboni

T Jagadeeswar Reddy

Jiuyu Liu

Lalit Kumar Sharma

Rajendra P Tangallapally

Anne V Edwards

Richard E Lee

The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Small molecule modulators of pantothenate kinases

The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Methods of treating disorders associated with castor

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Collierville, TN, United States of America

Mi Kyung Yun