Seegene, Inc.

Applied Materials, Inc.

Mi Hyun Jang

Young Jo Lee

Jong Yoon Chun

Sidharth Bhatia

Jeong Jin Hong

Han Bit Lee

Sejune Cheon

Joshua Maher

Embodiments disclosed herein include a method for use with a semiconductor processing tool. In an embodiment, the method comprises configuring the semiconductor processing tool, running a benchmark test on the semiconductor processing tool, providing hardware operating window (HOW) analytics, generating a design of experiment (DoE) using the HOW analytics, implementing process optimization, and releasing an iteration of the process recipe. In an embodiment, the method further comprises margin testing the iteration of the process recipe.

Physically-informed multi-system hardware operating windows

The present invention relates to a method for predicting the melting temperature (T) of an oligonucleotide, in particular a primer or probe, in a PCR or hybridization assay. The method of present invention can accurately predict the Tof an oligonucleotide in various reaction environments using the equations for Tcalculation, the equation including parameter values optimized for the reaction environment in which the oligonucleotide is to be used.

Method for predicting the melting temperature of oligonucleotide

The present invention relates to optimization logic for preparing an optimal combination of oligonucleotides hybridized with a plurality of target nucleic acid sequences, in a completely different approach from conventional methods, i.e., empirical and manual methods. In addition, the optimization logic of the present invention may be used to (i) preparing an oligonucleotide combination used to detect a plurality of target nucleic acid sequences with a target coverage of interest, (ii) selecting target nucleic acid sequences to be detected by a multiplex target detection with a highest target coverage by using a limited number of oligonucleotides, and (iii) determining a conserved region in a plurality of target nucleic acid sequences.

Methods for preparing optimal combination of oligonucleotides

The present invention relates to optimization logic for preparing an optimal introduction of degenerate bases and/or universal bases into an oligonucleotide used to detect a plurality of target nucleic acid sequences, in a completely different approach from conventional methods, i.e., empirical and manual methods. In addition, the optimization logic of the present invention may be used in (i) the preparation of an oligonucleotide into which a limited number of degenerate bases and/or universal bases are introduced for detecting a plurality of target nucleic acid sequences with a maximum target coverage, and (ii) the determination of a probing region in a plurality of target nucleic acid sequences.

Methods for preparing oligonucleotides for detecting target nucleic acid sequences with a maximum coverage

The present invention relates to a method for de-tecting an abnormal signal using two or more datasets. The present invention makes it possible to detect abnormal signals based on characteristics of abnormal signals commonly occurring in two or more datasets, which is effectively applied to datasets obtained by a multiplex PCR method.

Growing community of inventors

Seoul, South Korea

Mi Hyun Jang