Newtree Co., Ltd.

Aat Costech Co., Ltd.

Mi-Bo Kim

Jae-Kwan Hwang

Chang Hee Kim

Heechul Chung

Doun Kim

Changhee Kim

Jae Kwan Hwang

The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing aextract. More specifically, the present invention relates to: a pharmaceutical composition for preventing and treating muscle diseases, containing aextract; a food composition for preventing muscle diseases or improving muscular function; or a cosmetic for improving muscular function. Theextract of the present invention increases muscle formation by inducing muscular protein synthesis and muscle cell differentiation. Therefore, the extract is a natural product so as to be used safely without side effects, thereby being usable as an active ingredient of a pharmaceutical, food, or cosmetic composition exhibiting an excellent effect in preventing and treating muscle diseases or improving muscular function.

Composition for preventing and treating muscle diseases or improving muscular function, containing platycodon grandiflorum extract

A composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol,, adried powder, aextract,, adried powder or aextract is disclosed. Fucosterol,, adried powder, aextract,, adried powder or aextract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.

Composition for preventing, alleviating or treating muscle diseases or improving muscular function

The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing, as an active ingredient, at least one selected from the group consisting of morusin, kuwanon G, and a Mori Cortex Radicis extract. The Mori Cortex Radicis extract, morusin, or kuwanon G, according to the present invention, has an effect of remarkably enhancing muscular function by increasing the expression of p-mTOR protein involved in muscular protein synthesis, inhibiting the expression of mRNAs of MuRF-1 and atrogin-1 involved in muscular protein degradation, and increasing the expression of mRNAs of MyoD and myogenin involved in muscular differentiation. In addition, the present invention is a natural product so as to be used safely without side effects, thereby being usable in drugs, food, or cosmetics.

Methods for treating muscle wasting and degeneration diseases

The present invention relates to a composition for muscle function improvement or exercise ability enhancement, the composition including kirenol, aextract, or a fraction of theextract as an active ingredient. Kirenol, theextract containing kirenol, or theextract fraction according to the present invention has an excellent effect of increasing muscle mass by increasing the protein expression of p-mTOR, which is a major gene concerned with muscle functions. Also, kirenol, theextract containing kirenol, or theextract fraction according to the present invention has an effect of remarkably enhancing exercise ability by increasing the protein expression of PGC-1&#x3b1;, which is a major gene concerned with exercise ability. In addition, the present invention is a natural product, and thus is safe for use without side effects and can be used as a medicine or food.

Growing community of inventors

Seoul, South Korea

Mi-Bo Kim