Anaphore, Inc.

Mette Munch

Thor Las Holtet

Josephus Dirk Nieland

Helle Krogh Ottow

Mikkel Holmen Andersen

TNF binding polypeptides based on human tetranectin C-type lectin like domains (CTLD) with improved binding characteristics and improved efficacy. The polypeptides comprise a TNF binding domain having the amino acid sequence KRWS-RYF (SEQ ID NO:1). Also provided are methods of preparing the polypeptides of the invention. The polypeptides may be used for the preparation of pharmaceutical compositions, and for treatment of a subject having a pathology mediated by TNF, such as treatment of rheumatoid arthritis.

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Egå, Denmark

Mette Munch